CAS 192703-06-3; sr144528

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CAS:

192703-06-3

分子式:

C₂₉H₃₄ClN₃O

分子量:

476.05

英文名称:

sr144528

sr-144528

5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-n-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1h-pyrazole-3-carboxamide

用途:

SR144528 是一个有效且选择性的 CB2 受体拮抗剂，其 Ki 值为 0.6 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S880902

MACKLIN

SR144528

99%

752元/5mg; 1335元/10mg; 3011元/25mg; 9700元/100mg;

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储存：2-8℃
状态：白色到米黄色粉末

SML1899

Sigma-Aldrich

SR144528

≥98% (HPLC)

1538.21元/5 MG; 6199.1元/25 MG;

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产品说明

应用

SR144528 has been used as a cannabinoid CB2 receptor antagonist:

to study its blocking effect on the anti-dyskinetic functionality of HU-308
to study its effects on spontaneous excitatory postsynaptic currents (sEPSCs) from the globus pallidus neurons
to analyze its effect on the gastric emptying in rats

包装

5, 25 mg in glass bottle

生化/生理作用

SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist. SR144528 exhibited a Ki of 0.6 nM at CB2 compared to 400 nM at the related CB1 receptor.

基本信息

经验(实验)分子式	C₂₉H₃₄ClN₃O
分子量	476.05
MDL编号	MFCD05662316
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	−20℃
SMILES string	C[C@]12[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC=C(Cl)C(C)=C5)=C3)=O)C(C)(C)[C@@H](C2)CC1
InChI	1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
InChI key	SUGVYNSRNKFXQM-XRHWURSXSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3

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