| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| P797796 | MACKLIN | 盐酸哌唑嗪 | 2mM in DMSO | 186元/1ml; | 展开 |
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| P838220 | MACKLIN | 盐酸哌唑嗪 | BioChemika, ≥99% | 62元/1g; 195元/5g; 820元/25g; | 展开 |
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| P0938 | TCI | Prazosin Hydrochloride | >98.0%(T) | 540元/100MG; 1970元/1G; | 展开 |
基本信息 | 纯度/分析方法 | >98.0%(T) | | 分子式/分子量 | C19H21N5O4・HCl = 419.87 | | 外观与形状(20℃) | 固体 | | 应避免的情况 | 光 | | 相关CAS RN | 19216-56-9 | | Reaxys-RN | 4303561 | | PubChem物质ID | 87575055 | | Merck Index (14) | 7717 | | MDL编号 | MFCD00058177 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(Argentometric Titration) | min. 98.0 % |
物性(参考值) 安全信息 | 图形或危害标志 |  | | 信号词 | 警告 | | 危险性说明 | H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
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相关法规 |
| 126556 | J&K | Prazosin Hydrochloride | 98%, 一种α肾上腺素阻断剂, 可用于治疗高血压, 焦虑和恐慌症等 | 466元/100MG; 1701元/1G; | 展开 |
基本信息 | 分子式 | C19H21N5O4·HCl | | 分子量 | 419.87 | | 熔点 | 285 | | MDL编码 | MFCD00058177 | | Beilstein | 4303561 | | 存储条件 | Freezer -20℃ |
产品描述 Prazosin HCl是Quinazoline 衍生物，是一种新型的化学类抗高血压药物。 靶点（IC50 & Targe） ABCG Adrenergic Receptor MRP1 Potassium Channel 体外研究 Prazosin导致内皮细胞中血管内皮生长因子浓度以及仅当eNOS存在时血管生成的显著增加。Prazosin结合到α1肾上腺素能受体上，这些受体存在于所有粗血管周围的平滑肌细胞中。[1] Prazosin（0.1 nM）阻断perimesenteric神经电刺激引起的灌注压力的增加，但不显著降低外源性去甲肾上腺素的血管舒缩效应。[2] 体内研究 在骨骼肌中，Prazosin通过操纵血液动力学环境（流量，剪切应力）导致毛细管系统扩张。Prazosin诱导C57BL/6小鼠的趾长伸肌（EDL）的肌肉中的血管生成而不影响eNOS敲除小鼠。[1] 在大鼠中，Prazosin（0.5-2.0 毫克/千克）阻断Yohimbine诱导的食物和酒精摄取的复原，以及电击诱导的酒精摄取的复原。[3] 在大鼠中，Prazosin（0.2 毫克/千克，皮下注射）导致在多巴胺D2受体拮抗剂raclopride（0.05-0.20 毫克/千克，皮下注射）存在时条件回避反应的抑制的增强。[4] 在自由活动的大鼠中，Prazosin单独给药（1 毫克/千克，皮下注射）仅在最初10分钟略微降低水平活动，但它持续降低喂食。在自由活动的大鼠中，Prazosin有效地抑制任一剂量的MK-801引起的的运动刺激。[5] 参考文献 [1] Baum O, et al. Am J Physiol Heart Circ Physiol,?004, 287(5), H2300-H2308. [2] Donoso MV, et al. J Pharmacol Exp Ther,?997, 282(2), 691-698. [3] L?AD, et al. Psychopharmacology (Berl),?011, 218(1), 89-99. [4] Wadenberg ML, et al. J Neural Transm,?000, 107(10), 1229-1238. [5] Math?JM, et al. Eur J Pharmacol,?996, 309(1), 1-11. 安全信息 | 图形或危害标志 |  | | 提示语 | Warning | | 危险说明 | H302
H410 | | 防范说明 | P264
P270
P273
P301+P312
P330
P391
P501 | | UN号码 | 3077 | | 危险分类 | 9 | | 包装等级 | III | | RTECS | VA1350000 |
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| P7791 | Sigma-Aldrich | Prazosin Hydrochloride | ≥99.0% (HPLC) | 857元/50 MG; 3460.69元/250 MG; 10526.6元/1 G; | 展开 |
产品说明 一般描述 哌唑嗪是一种α-肾上腺素能阻滞剂。它被视为一种周围血管舒张抗高血压药物。哌唑嗪是喹唑啉的衍生物。 应用 盐酸哌唑嗪已用于： - 阻断介导小鼠交感血管收缩的 α1 肾上腺素能受体
- 作为 α1-肾上腺素受体阻滞剂，大鼠灌胃给药
- 作为血管扩张剂，与胰岛素一起注入小鼠左心室，评价其对肾功能的影响
生化/生理作用 外周 α1-肾上腺素能受体拮抗剂；血管扩张剂。哌唑嗪可用于治疗慢性创伤后应激障碍(PTSD)。它通过舒张血管起降血压作用，因此可用于治疗高血压。 特点和优势 这种化合物是 ADME 毒性和神经科学研究的特色产品。发现更多特色 ADME 毒性和神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物由 Pfizer 开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
该化合物出现在受体分类和信号转导手册的 α1-肾上腺素受体、α2-肾上腺素能受体和褪黑激素受体页，点击此处。 包装 无底玻璃瓶。内含物装在插入的融合锥内。 注意 吸湿；光敏感。 基本信息 | 经验(实验)分子式 | C19H21N5O4 · HCl | | 分子量 | 419.86 | | Beilstein | 4303561 | | EC 号 | 242-903-4 | | MDL编号 | MFCD00058177 | | PubChem化学物质编号 | 24277793 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥99.0% (HPLC) | | 溶解性 | H2O: 0.5 mg/mL
methanol: 6 mg/mL
dilute aqueous acid: insoluble | | 创始人 | Pfizer | | SMILES string | Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 | | InChI | 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H | | InChI key | WFXFYZULCQKPIP-UHFFFAOYSA-N | | Gene Information | human ... ADRA1A(148), ADRA1B(147), ADRA1D(146) |
安全信息 | 象形图 |  | | 警示用语： | Warning | | 危险声明 | H336 - H361fd - H373 | | 预防措施声明 | P201 - P202 - P260 - P271 - P280 - P308 + P313 | | 危险分类 | Repr. 2 - STOT RE 2 - STOT SE 3 | | 靶器官 | Central nervous system | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| P2680000 | | Prazosin Hydrochloride | European Pharmacopoeia (EP) Reference Standard | 1277.32元/ ; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 30 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C19H21N5O4 · HCl | | 分子量 | 419.86 | | Beilstein | 4303561 | | MDL编号 | MFCD00058177 | | PubChem化学物质编号 | 329820149 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 | | InChI | 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H | | InChI key | WFXFYZULCQKPIP-UHFFFAOYSA-N | | Gene Information | human ... ADRA1A(148), ADRA1B(147), ADRA1D(146) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H336 - H361fd - H373 | | 预防措施声明 | P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313 | | 危险分类 | Repr. 2 - STOT RE 2 - STOT SE 3 | | 靶器官 | Central nervous system | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 1554705 | USP | Prazosin Hydrochloride | United States Pharmacopeia (USP) Reference Standard | 3231.47元/350 MG; | 展开 |
产品说明 一般描述 Prazosin hydrochloride is an alpha-adrenergic blocking agent, employed as an antihypertensive drug for the treatment of high blood pressure. It lowers the blood pressure by binding to the alpha receptors thereby relaxing the blood vessels. 应用 It was used as an α1-adrenergic receptors antagonist, in a study performed to understand the influence of dopamine on uterine motility of rats in vitro. 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C19H21N5O4 · HCl | | 分子量 | 419.86 | | Beilstein | 4303561 | | MDL编号 | MFCD00058177 | | PubChem化学物质编号 | 329750933 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 | | InChI | 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H | | InChI key | WFXFYZULCQKPIP-UHFFFAOYSA-N | | Gene Information | human ... ADRA1A(148), ADRA1B(147), ADRA1D(146) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 - H315 - H319 - H335 - H361 | | 预防措施声明 | P201 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313 | | 危险分类 | Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3 | | 靶器官 | Respiratory system | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| PHR3099 | Supelco | Prazosin Hydrochloride | pharmaceutical secondary standard, certified reference material | 2477.42元/500 mg; | 展开 |
产品说明 一般描述 Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards 分析说明 These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. 其他说明 This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. 附注 To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive. 基本信息 | 经验(实验)分子式 | C19H21N5O4 · HCl | | 分子量 | 419.86 | | Beilstein | 4303561 | | MDL编号 | MFCD00058177 |
产品性质 | 等级 | certified reference material
pharmaceutical secondary standard | | CofA | current certificate can be downloaded | | 包装 | pkg of 500 mg | | application(s) | pharmaceutical | | 药典可追溯性 | traceable to USP 1554705 | | SMILES string | Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 | | InChI | 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H | | InChI key | WFXFYZULCQKPIP-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H336 - H361fd - H373 | | 预防措施声明 | P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313 | | 危险分类 | Repr. 2 - STOT RE 2 - STOT SE 3 | | 靶器官 | Central nervous system | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| BP399 | | Prazosin Hydrochloride | British Pharmacopoeia (BP) Reference Standard | 2299.24元/100 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C19H21N5O4 · HCl | | 分子量 | 419.86 | | Beilstein | 4303561 | | MDL编号 | MFCD00058177 |
产品性质 | 等级 | pharmaceutical primary standard | | 质量 | British Pharmacopoeia (BP) Reference Standard | | manufacturer/tradename | BP | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 | | InChI | 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H | | InChI key | WFXFYZULCQKPIP-UHFFFAOYSA-N | | Gene Information | human ... ADRA1A(148), ADRA1B(147), ADRA1D(146) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H336 - H361fd - H373 | | 预防措施声明 | P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313 | | 危险分类 | Repr. 2 - STOT RE 2 - STOT SE 3 | | 靶器官 | Central nervous system | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 047154 | Fluorochem | Prazosin Hydrochloride | >98.0%(T) | 3938元/1g; | 展开 |
基本信息 | CAS Number | 19237-84-4 | | MDL Number | MFCD00058177 | | Melting Point | 285℃ |
安全信息 | 图形或危害标志 | | | 危险性说明 | H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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