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CAS: 18997-19-8
分子式: C6H11ClO2
分子量: 150.61
沸点: 70-72℃(5
熔点: <-40 °C
中文名称: 
氯甲基新戊酸酯
氯甲基-2,2-二甲基丙酸酯
氯代甲基特戊硝
特戊酸氯甲酯
叔戊酸氯甲酯
新戊酸氯甲酯
2,2-二甲基丙酸氯甲酯
英文名称: 
2,2-dimethyl-propanoic aci chloromethyl ester
chloromethyl pivalate
Pivaloyloxymethyl chloride
Chloromethyl trimethylacetate
2,2-Dimethylpropionic Acid Chloromethyl Ester
Pivalic Acid Chloromethyl Ester
Trimethylacetic Acid Chloromethyl Ester
性质描述: 相对密度1.045,沸点146-148℃,折光率1.4170,闪点40℃。
生产方法: 由特戊酰氯经氯甲基化而得。将特戊酰氯、多聚甲醛加入反应锅,搅拌。加入无水氯化锌,在90-100℃下反应21h。然后减压蒸馏,收集71-75℃(6.67kPa)馏分即得成品。
用途: 有机中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
C742801MACKLIN特戊酸氯甲酯Standard for GC, ≥99.8%(GC)128元/5g;   展开
储存:室温, 易燃物区域
状态:液体
C805998MACKLIN特戊酸氯甲酯99%30元/25g;   50元/100g;   234元/500g;   999元/2.5kg;   展开
储存:室温,易燃物区域
状态:无色到淡黄色液体
折射率:n20/D 1.417(lit.)
P1012TCIChloromethyl Pivalate [Amino-Protecting Agent]>99.0%(GC)245元/25G;   650元/100G;   1850元/500G;   展开

基本信息

纯度/分析方法>99.0%(GC)
分子式/分子量C6H11ClO2 = 150.60
外观与形状(20℃)液体
储存在惰性气体下存放于惰性气体之中
应避免的情况湿气 (分解)
Reaxys-RN1560838
PubChem物质ID87575124
SDBS (AIST Spectral DB)21333
MDL编号MFCD00000884

技术规格

AppearanceColorless to Almost colorless clear liquid
Purity(GC)min. 99.0 %

物性(参考值)

沸点147 ℃
闪点40 ℃
比重1.04
折射率1.42

安全信息

图形或危害标志
信号词危险
危险性说明H314 : 造成严重皮肤灼伤和眼损伤。
H226 : 易燃液体和蒸气。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P240 : 容器和装载设备接地/等势联接。
P210 : 远离热源/火花/明火/热表面。禁止吸烟。
P233 : 保持容器密闭。
P243 : 采取防止静电放电的措施。
P241 : 使用防爆的电气/通风/照明设备。
P242 : 只能使用不产生火花的工具。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P370 + P378 : 火灾时:使用干砂、干粉或抗醇泡沫灭火。
P303 + P361 + P353 : 如皮肤(或头发)沾染:立即脱掉所有沾污的衣物。用水清洗皮肤/淋浴。
P301 + P330 + P331 : 如误吞咽:漱口。不要诱导呕吐。
P363 : 沾染的衣服清洗后方可重新使用。
P304 + P340 + P310 : 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。立即呼叫急救中心/医生。
P305 + P351 + P338 + P310 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。立即呼叫急救中心/医生。
P403 + P235 : 存放在通风良好的地方。保持低温。
P405 : 存放处须加锁。

运输信息

UN编号UN2924
类别3 / 8
包装类别 III
监管条件代码(*)
191650J&KChloromethyl pivalate99%108元/25G;   297元/100G;   1185元/500G;   展开

基本信息

分子式C6H11ClO2
分子量150.60
沸点146-148
闪点40
密度1.045
折光率(n20D)1.4170
MDL编码MFCD00000884
Beilstein1560838
EINECS 编号242-735-1

安全信息

图形或危害标志
提示语Warning
危险说明H226
H302
H312
H315
H319
H332
H335
防范说明P261
P280
P305+P351+P338
UN号码3272
危险分类3
包装等级III
TSCA
A11967Alfa AesarChloromethyl pivalate97%260元/25g;   696元/100g;   展开

应用
Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.

备注
Incompatible with strong oxidizing agents.

基本信息

MDL
MFCD00000884

EINECS
242-735-1

分子式
C6H11ClO2

分子量
150.60

沸点
146-148°

闪点
40°(104°F)

密度
1.045

折射率
1.4170

灵敏度
Ambient temperatures.

形态
Liquid

溶解性
Miscible with most organic solvents. Immiscible with water.

Beilstein
1560838

GHS危害和防范说明

GHS符号

Hazard Statements
H226-H314-H318
Flammable liquid and vapour.Causes severe skin burns and eye damage.Causes serious eye damage.

Precautionary Statements
P210-P260h-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Keep away from heat/sparks/open flames/hot surfaces. - No smoking.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
3

包装组
III

危险类别
10-34
Flammable.Causes burns.

安全等级
20-23-26-36/37/39-45-60
When using do not eat or drink.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

欧盟危险品标志

TSCA

035584FluorochemChloromethyl pivalate99%220元/1g;   220元/5g;   330元/25g;   770元/100g;   2200元/500g;   展开

基本信息

CAS Number18997-19-8
MDL NumberMFCD00000884
Boiling Point146-148℃
Density1.038

安全信息

图形或危害标志
危险性说明 H226: Flammable liquid and vapour.
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
防范说明 P210: Keep away from – No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof ./ equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P370 + P378: In case of fire: Use CO2, dry powder or foam for extinction.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P403 + P235: Store in a well-ventilated place. Keep cool.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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