应用
Reactant involved in they synthesis of biologically active molecules including small molecule ligands for the Stat3 SH2 domain, aryldisulfonamides with antibacterial activity, quinazoline analogs for the treatment of Gaucher disease, 17β-HSD2 inhibitors for the treatment of osteoporosis, isoindoline-5-propenehydroxamates for use as histone deactylase inhibitors.

备注
Moisture sensitive. Store under inert gas. Store away from moisture, oxidizing agents.

基本信息

MDL
MFCD00051747

分子式
C₇H₇ClO₂S

分子量
190.65

沸点
252-253°

闪点
107°(224°F)

密度
1.314

折射率
1.5480

灵敏度
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.

形态
Liquid

溶解性
Reacts with water.

Beilstein
2087865

GHS危害和防范说明

GHS符号

Hazard Statements
H314-H318
Causes severe skin burns and eye damage.Causes serious eye damage.

Precautionary Statements
P260h-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
8

包装组
II

危险类别
34
Causes burns.

安全等级
20-23-26-36/37/39-45-60
When using do not eat or drink.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

欧盟危险品标志

TSCA
否

产品说明

一般描述

间甲苯磺酰氯可通过冰醋酸中的氯化间硫甲酚进行合成。

应用

间甲苯磺酰氯可通过与均三甲苯反应合成间苯二甲酰间甲苯砜。
作为反应物参与合成生物活性分子，包括：

• Stat3 SH2结构域的小分子配体
• 用作组蛋白去乙酰化酶抑制剂的异吲哚啉-5-丙烯羟肟酯
• 作为FLT3激酶抑制剂的苯基吡唑胺基衍生物
• 具有抗细菌活性的芳二磺胺
• 用于治疗戈谢病的喹唑啉类似物
• 用于治疗骨质疏松症的17β-HSD2抑制剂

包装

5, 25 g in glass bottle

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H314
预防措施声明	P280 - P305 + P351 + P338 - P310
危险分类	Skin Corr. 1B
储存分类代码	8A - Combustible, corrosive hazardous materials
WGK	WGK 3
闪点(F)	225.0 °F - closed cup
闪点(C)	107.2 ℃ - closed cup
个人防护装备	Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

基本信息

安全信息

图形或危害标志
危险性说明	H314: Causes severe skin burns and eye damage. H318: Causes serious eye damage.
防范说明	P260: Do not breathe . P264: Wash hands thoroughly after handling. P280: Wear . P301 + P330 + P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see . on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to local regulations.