CAS 185991-07-5; amd 3465 hexahydrobromide

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CAS:

185991-07-5

分子式:

C₂₄H₃₈N₆·₆HBr

分子量:

896.070

英文名称:

amd 3465 hexahydrobromide

用途:

AMD3465是一种单一大环类CXCR4的拮抗剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

A873016

MACKLIN

AMD3465 hexahydrobromide

99%

352元/5mg;

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储存：-20℃
状态：粉末

A792379

MACKLIN

AMD3465 hexahydrobromide

10mM in Water

720元/1ml;

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储存：-20°C

SML1433

Sigma-Aldrich

AMD3465

≥98% (HPLC)

1399.43元/5 MG; 5643.95元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

AMD3465 is also termed as{N-[1,4,8,11-tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-2-(aminomethyl)pyridine}. It controls oncogenic signaling and invasiveness in vitro. It inhibits breast cancer growth and metastasis in vivo. As a chemokine receptor 4 (CXCR4) antagonist, AMD3465 is ten times more efficient than bicyclam AMD3100.
AMD3465 is a highly selective chemokine receptor CXCR4 antagonist with antiviral and anticancer activity. The chemokine receptor CXCR4 is expressed on a wide variety of leukocytes and is the predominant receptor for stromal cell-derived factor-1 (SDF1, CXCL12) in addition to acting as a co-receptor for HIV entry into cells. AMD3465 blocks surface binding of CXCL12 (SDF-1α). AMD3465 is an antagonist of SDF-1 ligand binding (K(i) of 41.7+/-1.2 nM). AMD3465 was found to halt the progression of an agressive childhood blood cancer, T-cell acute lymphoblastic leukemia (T-ALL), within two weeks of starting treatment in an animal model.

基本信息

经验(实验)分子式	C₂₄H₃₈N₆· 6HBr
分子量	896.07

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to light brown
溶解性	H₂O: 25 mg/mL, clear
储存温度	−20℃
InChI	1S/C24H38N6/c1-2-13-29-24(5-1)20-28-19-22-6-8-23(9-7-22)21-30-17-4-12-26-15-14-25-10-3-11-27-16-18-30/h1-2,5-9,13,25-28H,3-4,10-12,14-21H2
InChI key	CWJJHESJXJQCJA-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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