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CAS: 1837-91-8
分子式: C6H6Br6
分子量: 557.53
英文名称: 
1,2,3,4,5,6-hexabromo-cyclohexan
1,2,3,4,5,6-hexabromocyclohexane
推荐供应商
货号品牌产品名称规格包装、参考价格详情
J60853Alfa Aesar1,2,3,4,5,6-Hexabromocyclohexane1722元/1g;   7830元/5g;   展开

应用
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation

基本信息

MDL
MFCD00059127

分子式
C6H6Br6

分子量
557.50

灵敏度
Keep Cold.

形态
Solid

安全信息

TSCA

420132Sigma-AldrichJAK2 Inhibitor II-CAS 1837-91-8-CalbiochemThe JAK2 Inhibitor II, also referenced under CAS 1837-91-8, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic2165.23元/25 MG;   展开

产品说明

一般描述

A cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
JAK2 autophosphorylation
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Sandberg, E.M., et al. 2005. J. Med. Chem.48, 2526.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C6H6Br6
分子量557.54
MDL编号MFCD00059127

产品性质

质量水平100
测定≥97% (GC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 5 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChI keyQFQZKISCBJKVHI-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
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