CAS 1834610-75-1; 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]oxy]-n-1,2,4-thiadiazol-5-yl-benzenesulfonamide trihydrochloride; pf-06456384 trihydrochloride

CAS:

1834610-75-1

中文名称:

3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]oxy]-n-1,2,4-thiadiazol-5-yl-benzenesulfonamide trihydrochloride

benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]oxy]-n-1,2,4-thiadiazol-5-yl-, hydrochloride (1:3)

英文名称:

pf-06456384 trihydrochloride

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货号

品牌

产品名称

规格

包装、参考价格

PZ0386

Sigma-Aldrich

PF-06456384 trihydrochloride

≥98% (HPLC)

1387.85元/5 MG; 6982.94元/25 MG;

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产品说明

生化/生理作用

PF-06456384 is a highly potent and selective inhibitor against voltage-gated sodium channel NaV1.7 (SCN9A; IC50 = 0.01, <0.1, 75 nM against human, mouse, rat Nav1.7, respectively, by conventional patch clamp; human Nav1.7 IC50 = 0.58 nM by PatchExpress electrophysiology) with >300-fold selectivity over other human NaVs (IC50 = 3 nM/NaV1.2, 5.8 nM/NaV1.6, 75 nM/NaV1.7, 314 nM/NaV1.1, 1.45 μM/NaV1.4, 2.59 μM/NaV1.5, 6.44 μM/NaV1.3, 26 μM/NaV1.8).

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₃₅H₃₂F₃N₇O₃S₂ · 3HCl
分子量	829.18

产品性质

测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear
创始人	Pfizer
储存温度	room temp
SMILES string	O=S(C(C=C1)=CC(C#N)=C1OC2=C(C3=CC(CNCCC4CCNCC4)=NC=C3)C=C(C5=CC=CC(C(F)(F)F)=C5)C=C2)(NC6=NC=NS6)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable