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CAS: 183204-72-0
分子式: C9H12Cl2N4O2
分子量: 279.12759
英文名称: 
tipiracil hydrochloride
5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1h,3h)-pyrimidinedione hydrochloride
tpi hydrochloride
推荐供应商
货号品牌产品名称规格包装、参考价格
T795075MACKLIN盐酸替吡嘧啶10mM in DMSO186元/1ml;   咨询
储存:-20°C
T873319MACKLIN盐酸替吡嘧啶98%120元/250mg;   314元/1g;   1059元/5g;   3468元/25g;   咨询
储存:2-8°C
状态:白色到灰白色到米黄色粉末
SML1552Sigma-AldrichTipiracil hydrochloride≥98% (HPLC)1538.21元/10 MG;   6199.1元/50 MG;   咨询

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.

基本信息

经验(实验)分子式C9H11ClN4O2 · HCl
分子量279.12
MDL编号MFCD01571384
PubChem化学物质编号329825960
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性H2O: 5 mg/mL, clear (warmed)
储存温度2-8℃
SMILES string[H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O
InChI1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
InChI keyKGHYQYACJRXCAT-UHFFFAOYSA-N
Gene Informationhuman ... TYMP(1890)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
517760FluorochemTipiracil hydrochloride98+%1848元/1g;   5632元/5g;   9438元/10g;   咨询

基本信息

CAS Number183204-72-0
MDL NumberMFCD01571384
Melting Point245℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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