CAS 1801787-56-3; 6-oxo-4-trifluoromethyl-1,6-dihydro-pyridine-3-carboxylic acid [4-(4-methyl-piperazin-1-yl)-3′-morpholin-4-ylmethyl-biphenyl-3-yl]-amide; oicr-9429

CAS:

1801787-56-3

分子式:

C₂₉H₃₂F₃N₅O₃

分子量:

555.59

中文名称:

6-oxo-4-trifluoromethyl-1,6-dihydro-pyridine-3-carboxylic acid [4-(4-methyl-piperazin-1-yl)-3′-morpholin-4-ylmethyl-biphenyl-3-yl]-amide

英文名称:

oicr-9429

用途:

OICR-9429是一种有效的WDR5-MLL、WDR5-Histone3相互作用的拮抗剂，能在体外实验中降低急性髓性白血病细胞的活性。它与WDR5高亲和结合，Kd值为93 ± 28 nM。OICR-9429与WDR5高亲和力地结合（Kd=93±28 nM），并竞争性地破坏其与MLL的WIN肽段的相互作用(Kdisp=64±4 nM)[1]。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

O793137

MACKLIN

OICR-9429

10mM in DMSO

913元/1ml;

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储存：-20°C

O872713

MACKLIN

OICR-9429

99%

236元/5mg; 729元/25mg;

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储存：-20℃
状态：白色到浅棕色粉末

2062299

J&K

OICR-9429

98%, 一个新颖的相互作用的小分子Wdr5-MLL拮抗剂

732元/5MG; 1140元/10MG;

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基本信息

分子式	C₂₉H₃₂F₃N₅O₃
分子量	555.59
存储条件	Freezer -20℃

产品描述

OICR-9429是一种有效的WDR5-MLL、WDR5-Histone3相互作用的拮抗剂，能在体外实验中降低急性髓性白血病细胞的活性。它与WDR5高亲和结合，Kd值为93 ± 28 nM。

靶点（IC50 & Targe）

WDR5,93nM(Kd)

体外研究

OICR-9429与WDR5高亲和力地结合（Kd=93±28 nM），并竞争性地破坏其与MLL的WIN肽段的相互作用(Kdisp=64±4 nM)[1]。

细胞实验

Cell lines: 原代人类AML细胞

Concentrations: 5 μM

Incubation Time: 72 h

Method: 将增殖活跃的原代人类AML细胞以2000个/孔的密度接种于96孔板，用0.05%或OICR-9429对细胞进行处理。72小时后，测定细胞活性。

(Only for Reference)

参考文献

[1] Grebien F, et al. Nat Chem Biol. 2015, 11(8):571-8.

安全信息

图形或危害标志
危险说明	H302 H410
防范说明	P264 P270 P273 P301+P312 P330 P391 P501
UN号码	3077
危险分类	9
包装等级	III

SML1209

Sigma-Aldrich

OICR-9429

≥98% (HPLC)

1966.13元/5 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. For full characterization details, please see OICR-9429 on the Structural Genomics Consortium (SGC) website.

OICR-0547 is the negative control for the active probe, OICR-9429. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

OICR-9429 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他说明

OICR-9429 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the OICR-9429 probe summary on the Chemical Probes Portal website.

基本信息

经验(实验)分子式	C₂₉H₃₂F₃N₅O₃
分子量	555.59
MDL编号	MFCD18364451
PubChem化学物质编号	329825720
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to light brown
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
InChI	1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
InChI key	GMCOGJQJFDQZCP-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315
危险分类	Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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