| CAS: | 1798331-92-6 | |||||
| 分子式: | C16H13ClN2O2 | |||||
| 分子量: | 300.74 | |||||
| 英文名称: |
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| 用途: | QX77是分子伴侣介导的自噬 (CMA) 激活剂。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||
| Q881262 | MACKLIN | QX77 | 98% | 328元/5mg; 544元/10mg; | 展开 | ||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||
| Q797669 | MACKLIN | QX77 | 10mM in DMSO | 253元/1ml; | 展开 | ||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||
| SML2634 | Sigma-Aldrich | QX77 | ≥98% (HPLC) | 1453.88元/5 MG; 4684.02元/25 MG; | 展开 | ||||||||||||||||||||||||||
产品说明 生化/生理作用 QX77 is a chaperone-mediated autophagy (CMA) activator derived from the atypical retinoid AR7 that activates CMA by antagonizing retinoic acid receptor-α (RARα) signaling. QX77 rescues defective trafficking & lysosomal localization of the CMA receptor LAMP2A in cystinotic Ctns-/- MEFs and CTNS-KO human proximal tubule cells (PTCs) by restoring Rab11 expression and Rab11-positive vesicles trafficking to the level seen in wild-type cells (20 μM, 48 hrs). CMA activation by QX77 treatment (20 μM, 5 days) also significantly reduces toxic α-synuclein (α-syn) accumulation in PD patients iPSCs-derived astrocytes with LRRK2 G2019S mutation. 基本信息
产品性质
安全信息
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