CAS 1783816-74-9; nvs-pak1-1

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CAS:

1783816-74-9

分子式:

C₂₃H₂₅ClF₃N₅O

分子量:

479.93

英文名称:

nvs-pak1-1

(S)-3-(2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5h-dibenzo[b,e][1,4]diazepin-11-ylamino)-n-isopropylpyrrolidine-1-carboxamide

用途:

NVS-PAK1-1是有效，选择性的 PAK1 变构抑制剂，IC50值为5 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

N910315

MACKLIN

NVS-PAK1-1

98%

784元/5mg; 1205元/10mg;

咨询

储存：-20°C，密闭，干燥
状态：白色到米黄色固体

SML1867

Sigma-Aldrich

NVS-PAK1-1

≥98% (HPLC)

1677元/5 MG; 6765.81元/25 MG;

咨询

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC₅₀ value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

特点和优势

NVS-PAK1-1 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm

基本信息

经验(实验)分子式	C₂₃H₂₅ClF₃N₅O
分子量	479.93

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 30 mg/mL, clear
储存温度	2-8℃
SMILES string	FC(F)CN1C2=C(C=C(Cl)C=C2)C(N[C@H]3CCN(C(NC(C)C)=O)C3)=NC4=C1C=CC(F)=C4

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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