| CAS: | 176957-55-4 | ||
| 分子式: | C15H12OS2 | ||
| 分子量: | 272.39 | ||
| 熔点: | 222-223℃ | ||
| 英文名称: |
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| 用途: | CCT007093 是强效的PPM1D (WIP1)抑制剂，其IC50为 8.4 μM |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Z797113 | MACKLIN | (2E,5E)-2,5-二(2-噻吩基亚甲基)环戊酮 | 2mM in DMSO | 186元/1ml; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Z824576 | MACKLIN | (2E,5E)-2,5-二(2-噻吩基亚甲基)环戊酮 | 98% | 500元/10mg; 1120元/50mg; 1834元/100mg; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||
储存：2~8°C 状态：粉末 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| C9369 | Sigma-Aldrich | CCT007093 | ≥98% (HPLC), powder, yellow | 1156.54元/5 MG; 4626.2元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 应用 CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473. 包装 5, 25 mg in glass bottle 生化/生理作用 CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity. 特点和优势 This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. 基本信息
产品性质
安全信息
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