CAS 175013-84-0; tonabersat

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CAS:

175013-84-0

分子式:

C₂₀H₁₉ClFNO₄

分子量:

391.82

英文名称:

tonabersat

(3S-cis)-n-(6-acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2h-1-benzopyran-4-yl)-3-chloro-4-fluoro-benzamide

sb 220453

sb-220453

n-[(3S,4S)-6-acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2h-1-benzopyran-4-yl]-3-chloro-4-fluoro-benzamide

用途:

Tonabersat 是一种 gap-junction 调节剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

T881377

MACKLIN

Tonabersat

99%

2346元/5mg;

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储存：2-8℃
状态：白色到灰白色到米黄色到黄色粉末

SML1354

Sigma-Aldrich

Tonabersat

≥98% (HPLC)

1827.35元/5 MG; 7054.94元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Tonabersat (SB-220453) exhibits anticonvulsant property. It is a member of the family of novel benzoylamino-benzopyran compounds. Tonabersat is used as a therapeutic for trigeminal nerve-induced neurovascular reflexes. In addition, it acts as a putative migraine prophylactic agent containing an unique stereospecific binding site in the brain.
Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.

基本信息

经验(实验)分子式	C₂₀H₁₉ClFNO₄
分子量	391.82
MDL编号	MFCD00944458
PubChem化学物质编号	329825809
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -100 to -110°, c = 1 in methanol
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	CC(C1=CC=C2C([C@H](NC(C3=CC=C(F)C(Cl)=C3)=O)[C@H](O)C(C)(C)O2)=C1)=O
InChI	1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2,3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18-/m0/s1
InChI key	XLIIRNOPGJTBJD-ROUUACIJSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H400
预防措施声明	P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
危险分类	Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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