CAS 174671-46-6; tavaborole

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货号

品牌

产品名称

规格

包装、参考价格

T963876

MACKLIN

5-氟-1,3-二氢-1-羟基-2,1-苯并氧杂硼戊环

98%

111元/1g; 549元/5g; 1696元/25g;

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储存：-20°C, 干燥

T3775

TCI

Tavaborole

>98.0%(HPLC)

390元/250MG;

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基本信息

纯度/分析方法	>98.0%(HPLC)
分子式/分子量	C₇H₆BFO₂ = 151.93
外观与形状(20℃)	固体
储存温度	<0℃
储存在惰性气体下	存放于惰性气体之中
应避免的情况	湿气 (吸湿),加热
Reaxys-RN	10657796
MDL编号	MFCD10699483

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Melting point	130.0 to 134.0 ℃

物性(参考值)

熔点	132 ℃
水溶性	实际上不溶
在水中的溶解度	6,029 mg/l 25 ℃
溶解性(易溶于)	乙醇

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

Y10390

Alfa Aesar

Tavaborole

182元/100mg; 351元/250mg; 815元/1g; 2989元/5g;

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基本信息

分子量
151.93

SML1227

Sigma-Aldrich

Tavaborole

≥95% (HPLC)

1117.23元/10 MG; 4498.97元/50 MG;

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产品说明

一般描述

Tavaborole is a boron-based pharmaceutical agent. It has broad-spectrum oxaborole antifungal activity. Due to its low molecular weight, it facilitates maximal nail plate penetration than its predecessors.

包装

10, 50 mg in glass bottle

生化/生理作用

Tavaborole (AN2690) is a potent antifungal that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). Tavaborole forms a covalent adduct with the 3′ adenosine of tRNA(leu) at the editing site of fungal, but not bacterial LeuRS, locking the enzyme in an inactive conformation. Tavaborole was recently approved for the treatment of onychomycosis of the toenail in adults.

基本信息

经验(实验)分子式	C₇H₆BFO₂
分子量	151.93
NACRES	NA.77

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

425086

Fluorochem

5-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol

98%

682元/250mg; 1716元/1g; 5918元/5g;

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基本信息

CAS Number	174671-46-6
MDL Number	MFCD10699483
Melting Point	120-122℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .