| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| C804509 | MACKLIN | γ-环糊精 | 98% | 31元/5g; 71元/25g; 226元/100g; 997元/500g; 4100元/2.5kg; | 展开 |
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| C769291 | MACKLIN | γ-环糊精溶液 | 10mg/mL in H2O | 800元/1ml; | 展开 |
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| C769292 | MACKLIN | γ-环糊精溶液 | 5mg/mL in H2O | 600元/1ml; | 展开 |
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| C769293 | MACKLIN | γ-环糊精溶液 | 1mg/mL in H2O | 300元/1ml; | 展开 |
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| C6086 | MACKLIN | γ-环糊精 | 98%生物技术级 | 66元/5g; 146元/25g; 388元/100g; 1588元/500g; 5300元/2.5kg; | 展开 |
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| C0869 | TCI | γ-Cyclodextrin | >99.0%(HPLC) | 505元/5G; 1315元/25G; 4070元/100G; | 展开 |
基本信息 | 纯度/分析方法 | >99.0%(HPLC) | | 分子式/分子量 | C48H80O40 = 1297.13 | | 外观与形状(20℃) | 固体 | | 储存在惰性气体下 | 存放于惰性气体之中 | | 应避免的情况 | 湿气 (吸湿) | | PubChem物质ID | 87565927 | | SDBS (AIST Spectral DB) | 10927 | | Merck Index (14) | 2718 | | MDL编号 | MFCD00009595 |
技术规格 | Appearance | White powder to crystal | | Purity(HPLC) | min. 99.0 area% | | Specific rotation [a]20/D | +176.0 to +180.0 deg(C=1, H2O)(calcd.on anh.substance) | | Water | max. 12.0 % |
物性(参考值) | 比旋光度 [α]D | 178° (C=1,H2O) | | 水溶性 | 可溶 |
相关法规 |
| 474982 | J&K | γ-Cyclodextrin | 98% | 456元/5G; 1216元/25G; | 展开 |
基本信息 | 分子式 | C48H80O40 | | 分子量 | 1297.12 | | 熔点 | >300 | | MDL编码 | MFCD00009595 | | Beilstein | 78740 | | Merck | 14,2718 | | EINECS 编号 | 241-482-4 |
安全信息 | 防范说明 | P262 | | WGK | 2 | | RTECS | GU2293080 |
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| 925720 | J&K | γ-Cyclodextrin | 98% | 66元/5G; 288元/25G; | 展开 |
基本信息 | 分子式 | C48H80O40 | | 分子量 | 1297.12 | | 熔点 | >300 | | MDL编码 | MFCD00009595 | | Beilstein | 78740 | | Merck | 14,2718 | | EINECS 编号 | 241-482-4 |
安全信息 | 图形或危害标志 |  | | 提示语 | Warning | | 危险说明 | H315 H319 H335 | | 防范说明 | P264 P302+P352 P304+P340 P305+P351+P338 P332+P313 P337+P313 | | WGK | 2 | | RTECS | GU2293080 |
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| G0150000 | | Gammacyclodextrin | | 1277.32元/ ; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 120 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C48H80O40 | | 分子量 | 1297.12 | | Beilstein | 78740 | | MDL编号 | MFCD00009595 | | PubChem化学物质编号 | 329799799 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | [H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O | | InChI | 1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1 | | InChI key | GDSRMADSINPKSL-HSEONFRVSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 2 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| C4892 | Sigma-Aldrich | γ-Cyclodextrin | ≥98% | 3011.43元/1 G; 7966.67元/5 G; | 展开 |
基本信息 | 经验(实验)分子式 | C48H80O40 | | 分子量 | 1297.12 | | Beilstein | 78740 | | EC 号 | 241-482-4 | | MDL编号 | MFCD00009595 | | PubChem化学物质编号 | 24892736 | | NACRES | NA.22 |
产品性质 | 质量水平 | 200 | | 生物来源 | microbial | | 测定 | ≥98% | | 形式 | powder | | technique(s) | HPLC: suitable | | 溶解性 | 1 M NH4OH: 50 mg/mL | | SMILES string | [H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O | | InChI | 1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1 | | InChI key | GDSRMADSINPKSL-HSEONFRVSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 2 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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| 779660 | Sigma-Aldrich | γ-Cyclodextrin | Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis | 4900.64元/100 G; 7322.3元/1 KG; 61736.7元/25 KG; | 展开 |
产品说明 应用 γ-Cyclodextrin (γ-CD), a water-soluble cyclic oligosaccharide consisting of eight α-(1,4)-linked glucopyranose subunits, can be used in a wide range of applications including: - Synthesis of renewable and biocompatible metal-organic frameworks.
- Formation of inclusion complexes with a variety of guest molecules to increase their solubility in water and other polar solvents.
- Synthesis of γ-CD based nanogels and dendrimers as carriers and stabilizers for drug delivery applications.
法律信息 Cavamax is a registered trademark of Wacker Chemie AG 基本信息 | 经验(实验)分子式 | C48H80O40 | | 分子量 | 1297.12 | | Beilstein | 78740 | | EC 号 | 241-482-4 | | MDL编号 | MFCD00009595 | | PubChem化学物质编号 | 329768057 |
产品性质 | 质量水平 | 100 | | 等级 | Produced by Wacker Chemie AG, Burghausen, Germany, Life Science | | 测定 | 98.0-102.0% cyclodextrin basis | | 旋光性 | [α]/D 174.0 to 180.0° | | 杂质 | ≤0.5% related substances (sum) ≤0.50% impurities A, B and C (related substances) (single) ≤0.50% reducing substances ≤5 ppm heavy metals ≤50 ppm volatile organics | | 灼烧残渣 | ≤0.10% | | 缺失 | ≤11.0% loss on drying | | λ | 10 % in H2O | | 紫外吸收 | λ: 420 nm Amax: ≤0.20 | | SMILES string | [H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O | | InChI | 1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1 | | InChI key | GDSRMADSINPKSL-HSEONFRVSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 2 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| W779547 | Sigma-Aldrich | γ-Cyclodextrin | produced by Wacker Chemie AG, Burghausen, Germany, ≥98% (on dry basis) | 384.96元/100 G; 1964.83元/1 KG; 36980.7元/25 KG; | 展开 |
产品说明 应用 γ-Cyclodextrin (γ-CD), a water-soluble cyclic oligosaccharide consisting of eight α-(1,4)-linked glucopyranose subunits, can be used in a wide range of applications including: - Synthesis of renewable and biocompatible metal-organic frameworks.
- Formation of inclusion complexes with a variety of guest molecules to increase their solubility in water and other polar solvents.
- Synthesis of γ-CD based nanogels and dendrimers as carriers and stabilizers for drug delivery applications.
法律信息 Cavamax is a registered trademark of Wacker Chemie AG 基本信息 | 经验(实验)分子式 | C48H80O40 | | 分子量 | 1297.12 | | Beilstein | 78740 | | EC 号 | 241-482-4 | | MDL编号 | MFCD00009595 | | PubChem化学物质编号 | 329830761 | | NACRES | NA.22 |
产品性质 | 质量水平 | 200 | | 等级 | produced by Wacker Chemie AG, Burghausen, Germany | | reg. compliance | FDA 21 CFR 117 | | 描述 | derived from GMO corn | | 测定 | ≥98% (on dry basis) | | 杂质 | ≤0.5% reducing substances (determined as dextrose) ≤1.000 microorganisms per g ≤11% water ≤20 ppm volatile organics ≤5 ppm heavy metals 0 salmonella / E. Coli in 10 g | | 灼烧残渣 | ≤0.1% | | 痕量阳离子 | As: ≤1.3 ppm Pb: ≤1 ppm | | SMILES string | [H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O | | InChI | 1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1 | | InChI key | GDSRMADSINPKSL-HSEONFRVSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 2 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| C4930 | Sigma-Aldrich | γ-Cyclodextrin | powder, BioReagent, suitable for cell culture, ≥98% | 1288.2元/100 MG; 6219.52元/1 G; | 展开 |
产品说明 一般描述 环糊精属于环α-1,4-葡聚糖家族,由葡萄糖单元组成。该分子具有空心锥的形状。它具有亲水性外表面和疏水性内表面,因此环糊精可以形成包合物。γ-环糊精广泛用于食品和制药行业。环糊精是在环糊精糖基转移酶的作用下通过淀粉/淀粉衍生物的酶促转化而获得的。 包装 100 mg in poly bottle 1 g in poly bottle 应用 用于溶解非极性分子(如胆固醇)的分子,以用于细胞培养。 基本信息 | 经验(实验)分子式 | C48H80O40 | | 分子量 | 1297.12 | | Beilstein | 78740 | | EC 号 | 241-482-4 | | MDL编号 | MFCD00009595 | | PubChem化学物质编号 | 24892741 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 产品线 | BioReagent | | 测定 | ≥98% | | 形式 | powder | | technique(s) | cell culture | mammalian: suitable | | 溶解性 | 1 M NaOH: 25 mg/mL, clear to slightly hazy | | web metadata keyword.default | sigma-aldrich C4930,γ-Cyclodextrin powder, BioReagent, suitable for cell culture, Cyclomaltooctaose, Cyclooctaamylose, macromolecule solubilization reagent, fatty acids solubilization reagent, lipid solubilization reagent, cholesterol solubilization reagent. | | 运输 | ambient | | 储存温度 | room temp | | SMILES string | [H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O | | InChI | 1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1 | | InChI key | GDSRMADSINPKSL-HSEONFRVSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 2 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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| 779431 | Sigma-Aldrich | γ-Cyclodextrin | produced by Wacker Chemie AG, Burghausen, Germany, ≥90.0% cyclodextrin basis (HPLC) | 1450.51元/100 G; 3386.61元/1 KG; 51404元/25 KG; | 展开 |
产品说明 一般描述 Gamma-cyclodextrin (γ-CD) is a cyclic α-1,4-glucan linked oligosaccharide that is widely used in the food and pharmaceutical industries. In drug delivery, γ-CD can be used as a complexing agent because it forms an inclusion complex with a drug molecule. The complex of cyclodextrin increases the aqueous solubility and dissolution rate of the drug, which is useful for the delivery of the medical agent to a biological system. 应用 γ-Cyclodextrin can be used as a precursor for the synthesis of: - Octakis-(2,3-di-O-methyl-6-O-carboxymethyl)-γ-cyclodextrin sodium salt (ODMCM). ODMCM is used in capillary electrophoresis as a chiral resolving agent.
- Water-soluble cyclodextrin thioethers derivatives for the transportation of hydrophobic drugs.
法律信息 Cavasol is a registered trademark of Wacker Chemie AG 基本信息 | 经验(实验)分子式 | C48H80O40 | | 分子量 | 1297.12 | | Beilstein | 78740 | | EC 号 | 241-482-4 | | MDL编号 | MFCD00009595 | | PubChem化学物质编号 | 329768038 | | NACRES | NA.22 |
产品性质 | 等级 | produced by Wacker Chemie AG, Burghausen, Germany | | 质量水平 | 200 | | 测定 | ≥90.0% cyclodextrin basis (HPLC) | | 缺失 | ≤11.0% loss on drying | | SMILES string | [H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O | | InChI | 1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1 | | InChI key | GDSRMADSINPKSL-HSEONFRVSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 2 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 1154591 | USP | Gamma Cyclodextrin | United States Pharmacopeia (USP) Reference Standard | 3487.56元/200 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here. Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C48H80O40 | | 分子量 | 1297.12 | | Beilstein | 78740 | | MDL编号 | MFCD00009595 | | PubChem化学物质编号 | 329749477 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | [H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O | | InChI | 1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1 | | InChI key | GDSRMADSINPKSL-HSEONFRVSA-N |
安全信息 | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 2 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 927353 | Amethyst | γ-Cyclodextrin | 98%, 试剂级 | 55元/5G; 113元/25G; 310元/100G; 1184元/500G; | 展开 |
基本信息 | 分子式 | C48H80O40 | | 分子量 | 1297.12 | | 熔点 | >300 | | MDL编码 | MFCD00009595 | | Beilstein | 78740 | | Merck | 14,2718 | | EINECS 编号 | 241-482-4 |
安全信息 | 图形或危害标志 |  | | 提示语 | Warning | | 危险说明 | H315 H319 H335 | | 防范说明 | P264 P302+P352 P304+P340 P305+P351+P338 P332+P313 P337+P313 | | WGK | 2 | | RTECS | GU2293080 |
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| 023231 | Fluorochem | gamma-Cyclodextrin | 96% | 264元/1g; 550元/5g; 1980元/50g; 2816元/100g; | 展开 |
基本信息 | CAS Number | 17465-86-0 | | MDL Number | MFCD00009595 | | Melting Point | 267℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .
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