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CAS: 174635-69-9
分子式: C26H24N2O
分子量: 380.48
英文名称: 
sb 222200
(s)-3-methyl-2-phenyl-n-(1-phenylpropyl)-4-quinolinecarboxamide
用途: SB 222200是可逆的竞争性人NK受体抑制剂,对hNK-3受体的Ki为4.4 nM,能透过血脑屏障。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
S881382MACKLINSB-222200 ≥99%249元/10mg;   983元/50mg;   展开
储存:2-8℃
S5192Sigma-AldrichSB 222200≥98% (HPLC), solid2625.36元/10 MG;   10281.7元/50 MG;   展开

产品说明

应用

The pharmacodynamics profile of SB 222200 enables its use as a tool to study physiological and pathophysiological roles of NK-3 receptor in CNS-modulated behaviors.

包装

10, 50 mg in glass bottle

生化/生理作用

SB 222200 is a 2-phenyl-4-quinolinecarboxamides and a selective, reversible and competitive antagonist of human NK-3 receptor that effectively crosses the blood-brain barrier. It inhibits the NK-3 receptor-induced miosis or pupil constriction in conscious rabbits.1,2
Non-peptide NK3 tachykinin receptor antagonist.

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Glaxo­Smith­Kline

基本信息

经验(实验)分子式C26H24N2O
分子量380.48
MDL编号MFCD00944072
PubChem化学物质编号24278254
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色light yellow
溶解性DMSO: soluble ~28 mg/mL
H2O: insoluble
创始人GlaxoSmithKline
储存温度2-8℃
SMILES stringCC[C@H](NC(=O)c1c(C)c(nc2ccccc12)-c3ccccc3)c4ccccc4
InChI1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1
InChI keyMQNYRKWJSMQECI-QFIPXVFZSA-N
Gene Informationhuman ... TACR2(6865), TACR3(6870)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
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