CAS 17374-26-4; 4,5,6,7-四溴苯并三唑; 4,5,6,7-tetrabromobenzotriazole

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货号

品牌

产品名称

规格

包装、参考价格

T832954

MACKLIN

4,5,6,7-四溴苯基三唑

98%(HPLC)

29元/10mg; 70元/50mg; 190元/250mg; 525元/1g;

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储存：2~8℃,干燥,密封
状态：白色到浅黄色粉末到晶体

T798397

MACKLIN

4,5,6,7-四溴苯基三唑

10mM in DMSO

620元/1ml;

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储存：-20°C

T2920

TCI

4,5,6,7-Tetrabromobenzotriazole

>97.0%(T)(HPLC)

780元/10MG; 990元/50MG;

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基本信息

纯度/分析方法	>97.0%(T)(HPLC)
分子式/分子量	C₆HBr₄N₃ = 434.71
外观与形状(20℃)	固体
储存温度	0-10℃
应避免的情况	加热
Reaxys-RN	191078
PubChem物质ID	253661791
MDL编号	MFCD06411399

技术规格

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 97.0 area%
Purity(Neutralization titration)	min. 97.0 %

物性(参考值)

熔点	264 ℃
最大吸收波长	300(MeOH) nm

105538

J&K

4,5,6,7-Tetrabromobenzotriazole

97%, 选择性细胞渗透性酪蛋白激酶2(CK2)抑制剂

931元/50MG; 3083元/250MG;

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基本信息

分子式	C₆HBr₄N₃
分子量	434.71
熔点	262-266
MDL编码	MFCD06411399
Beilstein	191078
存储条件	Store at 2-8℃

安全信息

WGK

218697

Sigma-Aldrich

Casein Kinase II Inhibitor I-CAS 17374-26-4-Calbiochem

The Casein Kinase II Inhibitor I, also referenced under CAS 17374-26-4, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation &

1763.65元/10 MG;

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产品说明

一般描述

A cell-permeable benzotriazolo compound that acts as a highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC₅₀<1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC₅₀ = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC₅₀ = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).
A cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC₅₀ = 900 nM and 1.6 M, using rat liver and human recombinant CK2, respectively) and DYRK (IC₅₀<1 M for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC₅₀ = 20 and 60 M, using DNA and RNA substrate, respectively) and WNV (IC₅₀ = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I in DMSO, is also available.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Target IC₅₀: 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively; <1 µM for DYRK1a
Reversible: yes

警告

Toxicity: Carcinogenic / Teratogenic (D)

其他说明

Borowski, P., et al. 2003. Eur. J. Biochem.270, 1645.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Zien, P., et al. 2003. Biochem. Biophys. Res. Commun.306, 129.
Ruzzene, M., et al. 2002. Biochem. J.364, 41.
Sarno, S., et al. 2001. FEBS Lett.496, 44.
Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun.208, 418.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₆HBr₄N₃
分子量	434.71
MDL编号	MFCD06411399

产品性质

质量水平	100
测定	≥99% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChI key	OMZYUVOATZSGJY-UHFFFAOYSA-N