CAS 169590-41-4; 地拉考昔; deracoxib

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CAS:

169590-41-4

分子式:

C₁₇H₁₄F₃N₃O₃S

分子量:

397.37

中文名称:

地拉考昔

英文名称:

deracoxib

用途:

Deracoxib is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).

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货号

品牌

产品名称

规格

包装、参考价格

详情

S873677

MACKLIN

Deracoxib

99%

99元/100mg;

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储存：-20℃
状态：粉末

S795106

MACKLIN

Deracoxib

10mM in DMSO

185元/1ml;

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储存：-20°C

SML2014

Sigma-Aldrich

Deracoxib

≥98% (HPLC)

1387.85元/50 MG; 2613.8元/100 MG;

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产品说明

生化/生理作用

Deracoxib is an orally active cyclooxygenase-2 (COX-2) inhibitor with >48-fold selectivity over COX-1 (IC50 of 203-189 nM against COX-2-dependent PGE2 production vs. IC50 of 9.85-9.96 μM against COX-1-dependent TxB2 production in dog whole blood). Deracoxib is also reported to exhibit inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3) as well as positive modulatory effiacy toward 2-APB-stimulated transient receptor potential vanilloid 3 channel (TRPV3) activity.

基本信息

经验(实验)分子式	C₁₇H₁₄F₃N₃O₃S
分子量	397.37
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to brown
溶解性	DMSO: 2 mg/mL, clear
储存温度	room temp
InChI	1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25)
InChI key	WAZQAZKAZLXFMK-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

237584

Fluorochem

4-(3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl)benzenesulfonamide

95%

1760元/250mg; 4092元/1g;

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基本信息

CAS Number	169590-41-4
MDL Number	MFCD09837763

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