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CAS: 1674364-87-4
分子式: C15H23N7O4S
分子量: 397.45
中文名称: 
5′-s-[2-[[(ethylamino)carbonyl]amino]ethyl]-5′-thio-adenosine
英文名称: 
ds-437
推荐供应商
货号品牌产品名称规格包装、参考价格
D921314MACKLINDS-437≥98% (HPLC)493元/1mg;   咨询
储存：2-8°C
SML1516Sigma-AldrichDS-437≥98% (HPLC)1396.09元/5 MG;   4498.97元/25 MG;   咨询

产品说明

应用

DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.

包装

5, 25 mg in glass bottle

生化/生理作用

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.
DS-437 inhibits regulatory T cells (Tregs) function and methylation of forkhead box P3 (FOXP3) in 293T cells. DS-437 in combination with anti-p185erbB2/neu antibody 4D5 reduces tumor growth in CT26HER2 tumor-bearing mice.

其他说明

DS-437 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the DS-437 probe summary on the Chemical Probes Portal website.

基本信息

经验(实验)分子式C15H23N7O4S
分子量397.45
PubChem化学物质编号329825933
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度2-8℃
SMILES stringNC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSCCNC(NCC)=O)O3
InChI1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10+,11?,14-/m1/s1
InChI keyCACMCLIHCDTJHL-XNZUMOJTSA-N

安全信息

象形图GHS06
警示用语：Danger
危险声明H301
预防措施声明P301 + P330 + P331 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
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