| CAS: | 1638-41-1 | |||
| 分子式: | C12H4Cl6O4S | |||
| 分子量: | 456.9 | |||
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| 用途: | p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAPK with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38, and p38δ, respectively. |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||
| M911796 | MACKLIN | p38 MAPK Inhibitor IV | ≥98% | 1157元/5mg; | 展开 | ||||||||||||||||||||||||||||||||
储存：-20°C，密闭，干燥 | |||||||||||||||||||||||||||||||||||||
| SML0543 | Sigma-Aldrich | p38 MAP Kinase Inhibitor IV | ≥98% (HPLC) | 1156.54元/5 MG; | 展开 | ||||||||||||||||||||||||||||||||
产品说明 应用 p38 MAP激酶抑制剂IV被用于替代p38α激酶的激活，以检测HOXB7是否通过AKT / MAPK信号参与转移迁移和增殖过程。 包装 5, 25 mg in glass bottle 生化/生理作用 p38 MAP激酶抑制剂IV是p38α/βMAPK的ATP竞争性抑制剂，p38α和p38β的 MAPK IC50值分别为130 nM和550 nM。在1μM时，它对p38γ/σ，ERK1/2和JNK1/2/3的活性浓度、抑制率≤23%。在抑制LPS诱导hPBMC释放IL-1β方面，它比SB 203580更有效(100%vs、100μM抑制剂的抑制毒性50%)。最近的一项研究表明，p38 MAP激酶抑制剂IV可以持续显着着地增强体细胞的重编程和iPS细胞生成。 特点和优势 该化合物出现在受体分类和信号转导手册的 MAPKs页。要浏览手册其他页，点击此处。 基本信息
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| 506153 | Sigma-Aldrich | p38 MAP Kinase Inhibitor IV-CAS 1638-41-1-Calbiochem | The p38 MAP Kinase Inhibitor IV, also referenced under CAS 1638-41-1, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Deph | 2950.71元/10 MG; | 展开 | ||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor). 包装 10 mg in Plastic ampoule 警告 Toxicity: Harmful (C) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 其他说明 Liu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun.352, 656. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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