CAS 163630-79-3; 1′-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1h-2-benzofuran-3,4′-piperidine] fumarate salt; siramesine fumarate salt

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CAS:

163630-79-3

分子式:

C₃₄H₃₅FN₂O₅

分子量:

570.65

中文名称:

1′-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1h-2-benzofuran-3,4′-piperidine] fumarate salt

英文名称:

siramesine fumarate salt

lu 28-179

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S920790

MACKLIN

1'-[4-[1-(4-氟苯基)吲哚基-3-基]丁基]螺[-1H-2-苯并呋喃-3,4'-哌啶]富马酸盐

≥98% (HPLC)

1121元/5mg;

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储存：2-8°C

SML0976

Sigma-Aldrich

Siramesine fumarate salt

≥98% (HPLC)

1746.67元/5 MG; 5643.95元/25 MG;

咨询

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Siramesine is a blood-brain barrier penetrant, selective and potent sigma-2 receptor agonist, which exhibits potent and very long-lasting anxiolytic effects in rodents. Also, siramesine is a lysosome-destabilizing agent that causes lysosomal cell death in varies immortalized and cancer cell lines.
Siramesine or Lu 28-179 (1′-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4′-piperidine]) is considered as a drug for depression and anxiety. This lysosomotropic agent stimulates mitochondrial membrane potential (MMP) reduction and the production of ROS (reactive oxygen species).

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₃₀H₃₁FN₂O · C₄H₄O₄
分子量	570.65
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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