产品说明

应用

α₂-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease. It was also used in the control of the classical and the MBL pathway of complement activation.
通过与蛋白酶形成 1:1 复合物抑制各种内切蛋白酶。当蛋白酶裂解巨球蛋白"诱饵"序列时，巨球蛋白将重排并捕获蛋白酶。

生化/生理作用

α₂-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α₂-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α₂-M and protease-α₂-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α₂-M may contribute to tissue destruction during inflammation.
α₂-Macroglobulin (α₂M) is a multifunctional protein that is a broad spectrum protease inhibitor. α₂M is a large homotetrameric glycoprotein (720 kDa) that is connected by disulfide-linked dimers which non-covalently interact to give the quaternary structure. α₂M is found in normal plasma at a concentration of 220-230 mg/dl accounting for 3-5% of the total plasma protein.

包装

根据蛋白质含量确定包装尺寸

外形

由 0.02M Tris、0.13M 的甘氨酸 (pH 8.0) 以及 0.08M 海藻糖冻干制得。

分析说明

经检测，每位捐献者的血浆 HIV-1/HIV-2 抗体、HCV 和 HbSAg 抗体均为阴性。

基本信息

产品性质

安全信息

产品说明

应用

通过与蛋白酶形成 1:1 复合物抑制各种内切蛋白酶。当蛋白酶裂解巨球蛋白"诱饵"序列时，巨球蛋白将重排并捕获蛋白酶。

生化/生理作用

α₂-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α₂-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α₂-M and protease-α₂-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α₂-M may contribute to tissue destruction during inflammation.

分析说明

100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0
经检测，每位捐献者的血浆 HIV-1/HIV-2 抗体、HCV 和 HbSAg 抗体均为阴性。

其他说明

Conformational changes of α₂-M

基本信息

产品性质

安全信息