CAS 162049-83-4; 2-((3-三氟甲基)苯基)组胺二马来酸酯; 2-((3-trifluoromethyl)phenyl)histamine dimaleate

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货号

品牌

产品名称

规格

包装、参考价格

T4951

Sigma-Aldrich

2-((3-Trifluoromethyl)phenyl)histamine dimaleate

≥98% (HPLC), powder

2248.07元/5 MG;

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产品说明

应用

2-((3-Trifluoromethyl)phenyl)histamine dimaleate has been used to study the induction of goblet cell secretion in rats³. 2-((3-Trifluoromethyl)phenyl)histamine dimaleate has also been used to study the role of H1 receptor in COX-2 regulation and prostanoid homeostasis in human vascular endothelial cells⁴.

包装

5 mg in glass bottle

生化/生理作用

2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be the most potent and selective H₁ histamine receptor agonist of a panel of compounds in functional in vitro studies on histamine H₂, H₃, and other neurotransmitter receptors. It showed better potency at the guinea pig H₁ histamine receptor than at the human H₁ histamine receptor (pKi : 5.9). The selectivity of 2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be 2138 (H₁:H₂), > 64 (H₁:H₃), 1000 (H₁:M₃), 105 (H₁: a₁), 708 (H₁:β₁), and 71 (H₁:5HT_2A). 2-((3-Trifluoromethyl)phenyl)histamine dimaleate does not cross the blood-brain barrier.

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

2-((3-Trifluoromethyl)phenyl)histamine dimaleate is soluble in water at approximately 20 mg/ml.

基本信息

经验(实验)分子式	C₂₀H₂₀F₃N₃O₈
分子量	487.38
MDL编号	MFCD08277024
PubChem化学物质编号	329826803
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	off-white
溶解性	H₂O: ~20 mg/mL
储存温度	2-8℃
SMILES string	OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.NCCc1c[nH]c(n1)-c2cccc(c2)C(F)(F)F
InChI	1S/C12H12F3N3.2C4H4O4/c13-12(14,15)9-3-1-2-8(6-9)11-17-7-10(18-11)4-5-16;25-3(6)1-2-4(7)8/h1-3,6-7H,4-5,16H2,(H,17,18);21-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChI key	GGDUVPKRZGATLR-SPIKMXEPSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H315 - H318 - H335
预防措施声明	P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
危险分类	Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges