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CAS: 162011-90-7
分子式: C17H14O4S
分子量: 314.36
沸点: 577.6 ºC
熔点: 207 °C
中文名称: 
诺菲呋酮
4-[4-(甲磺酰基)苯基]-3-苯基-2(5)H-呋喃酮
英文名称: 
Rofecoxid
4-[4-(Methylsulfonyl)phenyl-3phenyl]-2(5H)-furanone
性质描述: 晶体粉末
用途: 非甾体抗炎药
推荐供应商
货号品牌产品名称规格包装、参考价格详情
R794070MACKLIN4-[4-(甲磺酰基)苯基]-3-苯基-2(5)H-呋喃酮10mM in DMSO405元/1ml;   展开
储存:-20°C
R824583MACKLIN4-[4-(甲磺酰基)苯基]-3-苯基-2(5)H-呋喃酮98%204元/250mg;   507元/1g;   1522元/5g;   展开
储存:2~8°C,密封
状态:灰白色-淡黄色
物化性质:晶体粉末
折射率:1.619
R0206TCIRofecoxib>98.0%(GC)490元/250MG;   1490元/1G;   展开

基本信息

纯度/分析方法>98.0%(GC)
分子式/分子量C17H14O4S = 314.36
外观与形状(20℃)固体
Reaxys-RN8269007
PubChem物质ID354335586
Merck Index (14)8248
MDL编号MFCD00935806

技术规格

AppearanceWhite to Yellow to Orange powder to crystal
Purity(GC)min. 98.0 %
Melting point207.0 to 211.0 ℃

物性(参考值)

熔点209 ℃
水溶性不溶
在水中的溶解度472 mg/l   25 ℃
溶解性(微溶于)甲醇
溶解度(极微溶)丙酮,乙醇

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#LU5135000
C46539Alfa AesarRofecoxib6941元/250mg;   展开

基本信息

Ref#
46539

分子式
C17H14O4S

分子量
284.26

GHS危害和防范说明

GHS符号

Hazard Statements
H302 H319

Precautionary Statements
P301+P330+P331 P312 P264 P280 P337+P313

SML0613Sigma-AldrichRofecoxib≥98% (HPLC)888.23元/10 MG;   4269.94元/50 MG;   展开

产品说明

应用

Rofecoxib has been used in high performance bioaffinity chromatography.

包装

10, 50 mg in glass bottle

生化/生理作用

Rofecoxib is derived from furanone and has the ability to cross human placenta. Along with anti-inflammatory action, it possesses analgesic and antipyretic properties. Cytosolic hepatic enzymes are responsible for the metabolism of rofecoxib. It is known to cause oligohydramnios and ductus arteriosus constrictions. Rofecoxib inhibits the action of CYP1A2 (cytochrome P450 family 1 subfamily A member 2). It might be associated with aseptic meningitis. Rofecoxib is known to ameliorate the risk of colorectal adenoma, but might contribute to toxicity.
Rofecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor with >800-fold COX-2 selectivity in CHO cells expressing human COX-1 and COX-2.

基本信息

经验(实验)分子式C17H14O4S
分子量314.36
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 5 mg/mL, clear (warmed)
储存温度2-8℃
InChI1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
InChI keyRZJQGNCSTQAWON-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
233845Fluorochem4-[4-(Methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one98%1386元/250mg;   3432元/1g;   14410元/10g;   展开

基本信息

CAS Number162011-90-7
MDL NumberMFCD00935806
Melting Point209℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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