| CAS: | 161058-83-9 | ||
| 分子式: | C12H17N5O | ||
| 分子量: | 247.3 | ||
| 熔点: | 199 °C(lit.) | ||
| 中文名称: |
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| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| N868103 | MACKLIN | NU2058 | 98% | 980元/250mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
储存：2-8°C 状态：白色到略淡黄色晶体或粉末 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| N793681 | MACKLIN | NU2058 | 10mM in DMSO | 880元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| N0958 | TCI | NU 2058 | >98.0%(HPLC) | 290元/20MG; 1190元/100MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
基本信息
技术规格
物性(参考值)
安全信息
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| 144505 | J&K | NU2058 | 99%, 一种CDK抑制剂, 抑制CDK2和CDK1 | 665元/5MG; 1140元/10MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
基本信息
产品描述 NU2058 is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay. It also potentiates melphalan (DMF 2.3), and monohydroxymelphalan (1.7), but not temozolomide or ionising radiation. 靶点（IC50 & Targe） CDK1 CDK2 Topo II 体外研究 NU2058 alters the transport of cisplatin, causing more Pt-DNA adducts, as well as sensitizing cells to cisplatin- and melphalan-induced DNA damage. However, the effects of NU2058 are independent of CDK2 inhibition[1]. In LNCaP cells and their Casodex-resistant derivative, LNCaP-cdxR, growth inhibition by NU2058 is accompanied by a concentration-dependent increase in p27 levels, reduced CDK2 activity and pRb phosphorylation, a decrease in early gene expression and G1 cell cycle phase arrest in both cell lines. NU2058 induces cell cycle reduction in S phase and inhibits phosphorylation of pRb. It induces a G1 arrest and increases p27 protein expression in LNCaP cells, showing no significant effect on p21 levels[2]. 细胞实验 Cell lines: The human head and neck cancer cell line, SQ20b Concentrations: 100 μM Incubation Time: 4 h Method: Cells are seeded into six-well plates (350,000 cells/well) and allowed to attach overnight. On the day of the experiment, growth media are replaced with media containing 100 μM of either NU2058, NU6102, NU6230 or DMSO (0.1% (v/v) final concentration) for 2 h followed by a further 2 h in the additional presence of cytotoxic drugs, unless otherwise indicated. For the radiation experiments, cells are treated for a total of 4 h with NU2058, and irradiated after the first 2 h. After treatment, the cells are washed twice with PBS, trypsinised, and replated into 100 mm Petri dishes at various cell densities (300-50,000 cells per plate). After approximately 12 days, media is removed, and cells are fixed with Carnoy's reagent (75% (v/v) methanol, 25% (v/v) acetic acid), stained with crystal violet (0.4% (w/v) in water) and colonies are counted. (Only for Reference) 参考文献 [1] Harrison LR, et al. Biochem Pharmacol. 2009, 77(10):1586-92. [2] Rigas AC, et al. Oncogene. 2007, 26(55):7611-9. 安全信息
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| N4286 | Sigma-Aldrich | NU2058 | >98% (HPLC) | 2000.82元/5 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 Selective cyclin-dependent kinase-2 (CDK2) inhibitor. 基本信息
产品性质
安全信息
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| 436931 | Fluorochem | 6-(Cyclohexylmethoxy)-9H-purin-2-amine | 95% | 1980元/250mg; 4928元/1g; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
基本信息
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