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Ibutamoren Mesylate

MCE 国际站：Ibutamoren Mesylate

品牌：MedChemExpress (MCE)

货号：HY-50844

CAS 号：159752-10-0

生物活性：甲磺酸伊布莫仑（MK-677）是一种强效的非肽类生长激素促分泌受体（GHSR）激动剂。甲磺酸伊布莫仑是一种口服有效的生长激素（GH）促分泌剂。

体内研究(In Vivo)：Ibutamoren mesylate (5 mg/kg/day) 导致狗的体重增加有统计学意义并增加血清 IGF-1 和 GH 水平。在研究的第 7 天或第 15 天，甲磺酸伊布他莫伦并未导致 CSF IGF-1 或 GH 水平显著升高[1]。用 GH 预处理小鼠可阻断甲磺酸异丁氨醇 (Ibutamoren mesylate，50 μg，ip) 对这些神经元的激活。在基因敲除小鼠中，GH 和奥曲肽均不能抑制甲磺酸伊布他莫仑对弓状神经元的激活[2]。MK-0677 的慢性口服给药与 GH 和 IGF-I 水平的显著增加有关，并在处理期间保持这种水平。MK-0677 给药后的 GH 曲线包括高于对照的间歇性增加[3]。MK-0677 在口服后显著增加峰值 GH 浓度。MK-0677 是一种有效的 GH 促分泌剂，口服或静脉注射时可立即、大幅度、持久地增加 GH 水平[4]。 MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：624.77

Formula：C28H40N4O8S2

性状：固体

颜色：White to light yellow

中文名称：伊布莫仑甲磺酸盐

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式： 4°C，密封保存，避免受潮 *溶剂保存：-80°C，6个月；-20°C，1个月（密封保存，避免受潮）

Animal Administration [2]：Compounds used are: Ibutamoren mesylate (50 μg), octreotide (100 μg), and mGH (30 μg). Mice are give an initial ip injection (0.1 mL) of either saline, octreotide or mGH, followed 10 min later by an ip injection (0.1 mL) of either saline or Ibutamoren mesylate. Thus, the first study comprised of the following groups: saline/saline, saline/Ibutamoren mesylate, mGH/saline, mGH/Ibutamoren mesylate saline/saline, saline/Ibutamoren mesylate, mGH/saline, mGH/Ibutamoren mesylate, and the second study of: saline/saline, saline/Ibutamoren mesylate, octreotide/saline, octreotide/Ibutamoren mesylate. Additionally, a number of mice are injected ip with hypertonic saline (0.2 mL, 1.5 M) to serve as positive controls for the immunocytochemistry. Ninety minutes after injection animals are terminally anesthetized with sodium pentobarbitone (60 mg/kg, ip) and perfused transcardially with heparinized saline followed by 4% paraformaldehyde in 0.1mol/Lphosphate buffer (PB, pH 7.4). Brains are then removed and placed in the same solution for 24 h before being stored at− 80°C until processing. Coronal sections of forebrain (40 μM) are cut on a freezing microtome and placed in 0.1mol/LPB containing Triton X-100 (PB-T, pH 7.4). Sections are incubated for 24 h at 4°C in Ab-2 Fos antibody (rabbit polyclonal; 1:1000 in 1% normal sheep serum). The antibody-antigen complex is localized with a 1-h incubation in biotinylated anti-rabbit Ig, followed by a 1-h incubation in avidin, biotinylated horseradish peroxidase. The reaction product is visualized using a glucose oxidase-diaminobenzidine-nickel method, and Fos-like immunoreactivity is visualized as a dense purple-black precipitate restricted to the nucleus. The number of c-fos positive nuclei in the arcuate and periventricular nuclei (six to eight sections per mouse) are counted double-blind and a group mean calculated (mean±sem). Statistical analysis is performed by a two-way ANOVA followed by an all pairwise multiple comparison of data with significance taken as P MCE尚未独立确认这些方法的准确性。 仅供参考。

文献引用：MCE 顾客使用本产品发表 5 篇科研文献

提供质量检测报告：Data Sheet、SDS、COA、HNMR、LCMS、产品使用指南

产品活性：Ibutamoren Mesylate (MK-677) 是一种有效的，非肽段类生长激素促分泌素受体 (GHSR) 激动剂。Ibutamoren Mesylate 是一种有效的，具有口服活性的生长激素 (GH) 促分泌素。

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客户发表文献：
[1]. Nature. 2026 Sep;657(8131):549-558.
[2]. Nature. 2026 Sep;657(8132):755-764.
[3]. Nature. 2026 Sep;657(8133):1027-1034.
[4]. Nature. 2026 Sep;657(8131):477-486.
[5].Nature. 2026 Sep;657(8132):789-799.
[6]. Nature. 2026 Sep;657(8131):517-524.
[7]. Nature. 2026 Sep;657(8133):1045-1052.
[8]. Cell. 2026 Sep 14:S0092-8674(26)01003-2.
[9]. Cell. 2026 Sep 3;189(18):5688-5705.e13.
[10]. Cell. 2026 Sep 2:S0092-8674(26)00937-2.

参考文献：
[1]. Prahalada S, et al. Insulin-like growth factor-1 and growth hormone (GH) levels in canine cerebrospinal fluid are unaffected by GH or GH secretagogue (MK-0677) administration. Horm Metab Res. 1999 Feb-Mar;31(2-3):133-7.
[2]. Zheng H, et al. Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol. 1997 Oct;11(11):1709-17.
[3]. Hickey GJ, et al. Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles. J Endocrinol. 1997 Feb;152(2):183-92.
[4]. Jacks T, et al. MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles. Endocrinology. 1996 Dec;137(12):5284-9.