| CAS: | 155877-83-1 | |||
| 分子式: | C29H3N2O2 | |||
| 分子量: | 438.56 | |||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||
| L918725 | MACKLIN | LE 135 | ≥98% | 1070元/5mg; 1712元/10mg; 3424元/25mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||
储存：2-8°C | |||||||||||||||||||||||||||||||||||||||||||
| SML0809 | Sigma-Aldrich | LE 135 | ≥98% (HPLC) | 1398.6元/5 MG; 4510.54元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||
产品说明 应用 LE 135 has been used for in vitro islet treatment. 包装 5, 25 mg in glass bottle 生化/生理作用 LE135 is a retinoic acid receptor (RAR) antagonist with selectivity for RARβ (Ki = 220 nM) over RARα (Ki = 1.4 μM). LE135 inhibits retinoic acid-induced transcriptional activation of RARβ (>70% inhibition at 10 μM), but not RARα, RARγ or retinoid X receptor α (RXRα). There is high interest in retinoic acid receptors for cancer and for differentiation studies. LE135 has been shown to inhibit retinoid Am80-induced differentiation of human promyelocytic leukemia HL-60 cells with an IC50 value of 0.2 μM. LE135 has been used to study the role of a retinoic acid receptor-β (RARβ) on the differentiation of mesenchymal stem cells, and was found to inhibit the neuronal differentiation promoting effects of all-trans retinoic acid (ATRA) on mesenchymal stem cells. 特点和优势 This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. 基本信息
产品性质
安全信息
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