| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| T797831 | MACKLIN | 6-硫鸟嘌呤 | 10mM in DMSO | 401元/1ml; | 展开 |
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| T819095 | MACKLIN | 6-硫鸟嘌呤 | 98% | 46元/250mg; 100元/1g; 302元/5g; 998元/25g; 3787元/100g; | 展开 |
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| T0212 | TCI | 6-Thioguanine | >95.0%(HPLC) | 435元/1G; 1310元/5G; | 展开 |
基本信息 | 纯度/分析方法 | >95.0%(HPLC) | | 分子式/分子量 | C5H5N5S = 167.19 | | 外观与形状(20℃) | 固体 | | Reaxys-RN | 1074099 | | PubChem物质ID | 87576202 | | SDBS (AIST Spectral DB) | 4204 | | Merck Index (14) | 9337 | | MDL编号 | MFCD00233553 |
技术规格 | Appearance | Light orange to Yellow to Green powder to crystal | | Purity(HPLC) | min. 95.0 area% |
安全信息 | 图形或危害标志 |  | | 信号词 | 危险 | | 危险性说明 | H301 : 吞咽会中毒。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。
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相关法规 运输信息 | UN编号 | UN2811 | | 类别 | 6.1 | | 包装类别 | III | | 监管条件代码(*) | |
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| 268355 | J&K | 6-Thioguanine | 98%, 一种抗白血病和免疫抑制剂 | 243元/500MG; 413元/1G; 1244元/5G; | 展开 |
基本信息 | 分子式 | C5H5N5S | | 分子量 | 167.20 | | 熔点 | 300 | | MDL编码 | MFCD00233553 | | Beilstein | 157765 | | EINECS 编号 | 205-827-2 |
产品描述 Thioguanine是一种嘌呤类的抗代谢药物，抑制了DNMT1的活性，广泛用于治疗急性淋巴细胞白血病，自身免疫性疾病（如克罗恩氏病，类风湿关节炎）和器官移植接受患者。 靶点（IC50 & Targe） DNMT1 体外研究 Thioguanine掺入改变在etoposide存在和不存在时拓扑异构酶II诱导的DNA切割。[1] Thioguanine改变双链DNA的结构和降低双链DNA的热稳定性，但在6SG可以形成存在双链DNA。[2] 在两个错配修复熟练和缺陷型HCT116和HeLa细胞中，6-Thioguanine诱导在类似的凋亡。[3]6-Thioguanine能结合到DNA，不像典型的DNA碱基，它是一种强的UVA的发色团在342纳米具有最大吸收。6-Thioguanine是光敏剂和活性氧源。[4] 体内研究 在异种移植物模型中，6-Thioguanine是和PARP抑制剂一样有效的选择性杀死BRCA2缺陷肿瘤。6-Thioguanine有效杀死BRCA1缺陷型PARP抑制剂抗性的肿瘤。6-Thioguanine可以杀死细胞，肿瘤通过BRCA2基因的遗传逆转获得了抗PARP抑制剂的抗性。[5] 参考文献 [1] Krynetskaia NF, et al. FASEB J,?000, 14(14), 2339-2344. [2] Marathias VM, et al. Nucleic Acids Res,?999, 27(14), 2860-2867. [3] Yamane K, et al. Clin Cancer Res,?005, 11(6), 2355-2363. [4] Brem R, et al. Photochem Photobiol,?012, 88(1), 5-13. [5] Issaeva N, et al. Cancer Res,?010, 70(15), 6268-6276. 安全信息 | 图形或危害标志 | | | 提示语 | Danger | | 危险说明 | H301 | | 防范说明 | P301+P310 | | UN号码 | 2811 | | 危险分类 | 6.1 | | 包装等级 | III | | WGK | 3 | | RTECS | UP0740000 | | TSCA | 否 |
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| B21280 | Alfa Aesar | 6-Thioguanine | 98% | 1586元/1g; 7039元/5g; | 展开 |
应用
6-Thioguanine acts as an antineoplastic and purine antimetabolite. It is also useful as an inhibition of stimulated expression of TNF-related apoptosis-inducing ligand (TRAIL) protein. It is involved in the treatment of acute leukemias and Psoriasis. Further, it is used for the treatment of ulcerative colitis and autoimmune diseases. 备注
Incompatible with strong oxidizing agents. 基本信息 MDL
MFCD00233553 EINECS
205-827-2 分子式
C5H5N5S 分子量
167.19 熔点
>360° 灵敏度
Ambient temperatures. 形态
Powder 溶解性
Soluble in dilute solutions of alkali hydroxides and hot alcohol. Insoluble in water. Beilstein
157765 Merck
14,9337 GHS危害和防范说明 GHS符号
Hazard Statements
H301
Toxic if swallowed. Precautionary Statements
P264-P270-P301+P310a-P321-P405-P501a
Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Do not eat, drink or smoke when using this product.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations. 安全信息 危险等级
6.1 包装组
III 危险类别
25
Toxic if swallowed. 安全等级
20-36-45-60
When using do not eat or drink.Wear suitable protective clothing.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste RTECS
UP0740000 TSCA
否 |
| A4882 | Sigma-Aldrich | 6-Thioguanine | ≥98% | 610.79元/100 MG; 781.04元/250 MG; 1387.79元/500 MG; 2311.22元/1 G; 9136.19元/5 G; | 展开 |
产品说明 一般描述 6-硫鸟嘌呤是鸟嘌呤的变体，在嘌呤环的 N-7 位有氢键。它与胞嘧啶的结合改变了碱基堆积的维度。6-硫鸟嘌呤是治疗炎症性肠病 (IBD) 的有效药物，可导致肝脏结节性再生性增生 (NRH)。 应用 6-硫鸟嘌呤已用于：
- 诱导结直肠癌细胞系 HCT116 的自噬和凋亡
- 在中国仓鼠肺成纤维细胞培养 V79 的突变和存活试验中作为选择标记
- 在 4T1-luc 细胞的克隆源性肺转移试验中作为选择标记
包装 1, 5 g in glass bottle
100, 250, 500 mg in glass bottle 生化/生理作用 核糖基化并通过与天然嘌呤碱相同的途径磷酸化；作为核苷酸，抑制参与核酸合成的多种细胞过程。作为白血病的有效治疗方法已有悠久的历史。
用于治疗白血病的抗代谢药。与次黄嘌呤和鸟嘌呤竞争次黄嘌呤-鸟嘌呤磷酸核糖转移酶，后者是生成嘌呤核苷酸的关键步骤。 基本信息 | 经验(实验)分子式 | C5H5N5S | | 分子量 | 167.19 | | Beilstein | 157765 | | EC 号 | 205-827-2 | | MDL编号 | MFCD00233553 | | PubChem化学物质编号 | 24890748 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 测定 | ≥98% | | 形式 | powder | | mp | ≥300 ℃ (lit.) | | SMILES string | NC1=Nc2nc[nH]c2C(=S)N1 | | InChI | 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) | | InChI key | WYWHKKSPHMUBEB-UHFFFAOYSA-N | | Gene Information | human ... IMPDH1(3614), IMPDH2(3615) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P301 + P310 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
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| 1660000 | USP | Thioguanine | United States Pharmacopeia (USP) Reference Standard | 3036.37元/200 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 核糖基化并通过与天然嘌呤碱相同的途径磷酸化；作为核苷酸，抑制参与核酸合成的多种细胞过程。作为白血病的有效治疗方法已有悠久的历史。 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C5H5N5S | | 分子量 | 167.19 | | Beilstein | 157765 | | MDL编号 | MFCD00233553 | | PubChem化学物质编号 | 329751279 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | mp | ≥300 ℃ (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | NC1=Nc2nc[nH]c2C(=S)N1 | | InChI | 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) | | InChI key | WYWHKKSPHMUBEB-UHFFFAOYSA-N | | Gene Information | human ... IMPDH1(3614), IMPDH2(3615) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P301 + P330 + P331 + P310 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| A4660 | Sigma-Aldrich | 6-Thioguanine | Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma | 302.84元/2.5 MG; | 展开 |
产品说明 应用 在杂交瘤形成应用中作为选择剂。 生化/生理作用 核糖基化并通过与天然嘌呤碱相同的途径磷酸化；作为核苷酸，抑制参与核酸合成的多种细胞过程。作为白血病的有效治疗方法已有悠久的历史。 重悬 10mL 无菌细胞培养基可复原一小瓶本品。储存液足以制备 500mL 培养基。最终工作浓度：30μM 2-氨基-6-巯基嘌呤。 法律信息 Hybri-Max is a trademark of sigma-aldrich Co. LLC 基本信息 | 经验(实验)分子式 | C5H5N5S | | 分子量 | 167.19 | | Beilstein | 157765 | | EC 号 | 205-827-2 | | MDL编号 | MFCD00233553 | | PubChem化学物质编号 | 24890892 | | NACRES | NA.75 |
产品性质 | 质量水平 | 200 | | 生物来源 | synthetic (organic) | | 等级 | Hybri-Max™ | | 无菌性 | γ-irradiated | | 产品线 | BioXtra | | 测定 | ~98% | | 形式 | lyophilized powder | | 浓度 | 50 × | | technique(s) | cell culture | hybridoma: suitable | | 杂质 | endotoxin, tested | | mp | ≥300 ℃ (lit.) | | 溶解性 | 1 M NaOH: 50 mg/mL, clear to slightly hazy | | web metadata keyword.default | Selection agent, purine antimetabolite, thiopurine, mutagen, cytotoxin | | 储存温度 | room temp | | SMILES string | NC1=Nc2nc[nH]c2C(=S)N1 | | InChI | 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) | | InChI key | WYWHKKSPHMUBEB-UHFFFAOYSA-N | | Gene Information | human ... IMPDH1(3614), IMPDH2(3615) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P301 + P310 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
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| BP878 | | Tioguanine | British Pharmacopoeia (BP) Reference Standard | 2144.18元/100 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 核糖基化并通过与天然嘌呤碱相同的途径磷酸化；作为核苷酸，抑制参与核酸合成的多种细胞过程。作为白血病的有效治疗方法已有悠久的历史。 包装 Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C5H5N5S | | 分子量 | 167.19 | | Beilstein | 157765 | | MDL编号 | MFCD00233553 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | BP | | mp | ≥300 ℃ (lit.) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | NC1=Nc2nc[nH]c2C(=S)N1 | | InChI | 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) | | InChI key | WYWHKKSPHMUBEB-UHFFFAOYSA-N | | Gene Information | human ... IMPDH1(3614), IMPDH2(3615) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P264 - P270 - P301 + P310 + P330 - P405 - P501 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 358091 | Fluorochem | 2-Amino-1,7-dihydro-6H-purine-6-thione | 95+% | 418元/1g; 1078元/5g; 4378元/25g; 13882元/100g; | 展开 |
基本信息 | CAS Number | 154-42-7 | | MDL Number | MFCD00005568 | | Melting Point | 360℃ |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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