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CAS: 1508-75-4
分子式: C17H20N2O2
分子量: 284.35
熔点: 98 °C
中文名称: 
托吡卡胺
托品酰胺
英文名称: 
N-ethyl-α-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
n-ethyl-alpha-(hydroxymethyl)-n-(4-pyridinylmethyl)-benzeneacetamid
bistropamide
epitromina
n-ethyl-2-phenyl-n-(4-pyridylmethyl)-hydracrylamid
mydriacyl
mydriat
mydrin
mydrum
n-ethyl-alpha-(hydroxymethyl)-n-(4-pyridinylmethyl)benzeneacetamide
ro 1-7683
tropicamide
visumidriatic
展开更多英文名
用途: 抗胆碱药，散瞳药。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
T795527MACKLIN托吡卡胺10mM in DMSO408元/1ml;   展开
储存：-20°C
T820238MACKLIN托吡卡胺≥99.0%56元/1g;   196元/5g;   866元/25g;   展开
储存：2~8°C
状态：白色固体
T1470TCITropicamide>99.0%(T)(HPLC)880元/10G;   展开

基本信息

纯度/分析方法>99.0%(T)(HPLC)
分子式/分子量C17H20N2O2 = 284.36
外观与形状(20℃)固体
Reaxys-RN285563
PubChem物质ID87577232
Merck Index (14)9780
MDL编号MFCD00058580

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 99.0 area%
Purity(Nonaqueous Titration)min. 99.0 %
Melting point97.0 to 100.0 ℃

物性(参考值)

熔点98 ℃
最大吸收波长254(HCl aq.) nm
水溶性实际上不溶
溶解性(可溶于)乙醇,氯仿
溶解度(极微溶)乙醚

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#CY1487860
408413J&KTropicamide99%, 一种有效选择性M4拮抗剂1188元/10G;   展开

基本信息

分子式C17H20N2O2
分子量284.35
熔点97-100
MDL编码MFCD00058580
Beilstein285563
Merck14,9780
EINECS 编号216-140-2
存储条件Freezer -20℃

产品描述

Tropicamide是一种抗胆碱，毒蕈碱受体M4亚型的选择性拮抗剂，IC50为8.0 nM。

靶点（IC50 & Targe）

M4 mAChR,8nM

安全信息

图形或危害标志
提示语Warning
危险说明H302
H312
H315
H317
H319
H332
H335
防范说明P261
P280
P305+P351+P338
WGK3
RTECSCY1487860
T9778Sigma-AldrichTropicamidesolid980.15元/100 MG;   3342.43元/1 G;   展开

产品说明

应用

Tropicamide has been used for studying the regulation of fragile X behavior in male mice. 1% tropicamide has also been used for dilating mice pupils.

生化/生理作用

M4 muscarinic acetylcholine receptor antagonist.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

制备说明

Tropicamide is soluble in 45% (w/v) aqueous 2-hydroxypropyl-beta-cyclodextrin (4.3 mg/mL) and ethanol (5.6 mg/mL).

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T9778.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式C17H20N2O2
分子量284.35
EC 号216-140-2
MDL编号MFCD00058580
PubChem化学物质编号24277879
NACRESNA.77

产品性质

质量水平100
形式solid
颜色 white
溶解性45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL
ethanol: 5.6 mg/mL
H2O: insoluble
储存温度2-8℃
SMILES stringCCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2
InChI1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChI keyBGDKAVGWHJFAGW-UHFFFAOYSA-N
Gene Informationhuman ... CHRM3(1131), CHRM4(1132)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302 + H312 + H332 - H315 - H317 - H319 - H335
预防措施声明P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
T2580000TropicamideEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H20N2O2
分子量284.35
MDL编号MFCD00058580
PubChem化学物质编号329826715
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2
InChI1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChI keyBGDKAVGWHJFAGW-UHFFFAOYSA-N
Gene Informationhuman ... CHRM3(1131)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302 + H312 + H332 - H315 - H317 - H319 - H335
预防措施声明P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0001316Tropicamide for peak identificationEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H20N2O2
分子量284.35
MDL编号MFCD00058580
PubChem化学物质编号329831361
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2
InChI1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChI keyBGDKAVGWHJFAGW-UHFFFAOYSA-N
Gene Informationhuman ... CHRM3(1131)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302 + H312 + H332 - H315 - H317 - H319 - H335
预防措施声明P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHR3152SupelcoTropicamidepharmaceutical secondary standard, certified reference material2006.37元/500 mg;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C17H20N2O2
分子量284.35
MDL编号MFCD00058580

产品性质

等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
application(s)pharmaceutical
药典可追溯性traceable to USP 1699005
储存温度2-8℃
SMILES stringCCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2
InChI1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChI keyBGDKAVGWHJFAGW-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语：Warning
危险声明H302 + H312 + H332 - H315 - H317 - H319 - H335
预防措施声明P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1699005USPTropicamideUnited States Pharmacopeia (USP) Reference Standard2633.96元/200 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C17H20N2O2
分子量284.35
MDL编号MFCD00058580
PubChem化学物质编号329751428
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2
InChI1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChI keyBGDKAVGWHJFAGW-UHFFFAOYSA-N
Gene Informationhuman ... CHRM3(1131)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302 + H312 + H332 - H315 - H317 - H319 - H335
预防措施声明P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP1047TropicamideBritish Pharmacopoeia (BP) Reference Standard2071.17元/50 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H20N2O2
分子量284.35
MDL编号MFCD00058580

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringCCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2
InChI1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChI keyBGDKAVGWHJFAGW-UHFFFAOYSA-N
Gene Informationhuman ... CHRM3(1131)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302 + H312 + H332 - H315 - H317 - H319 - H335
预防措施声明P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
175900FluorochemTropicamide95+%220元/250mg;   440元/1g;   1584元/5g;   2574元/10g;   展开

基本信息

CAS Number1508-75-4
MDL NumberMFCD00058580
Melting Point96-99℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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