| CAS: | 149719-06-2 | ||||||||
| 分子式: | C16H24Cl2N2O3 | ||||||||
| 分子量: | 363.28 | ||||||||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||
| R913444 | MACKLIN | 3-(哌啶-1-基)丙基 4-氨基-5-氯-2-甲氧基苯甲酸酯 盐酸盐 | 95% | 4061元/250mg; 5866元/500mg; | 咨询 | ||||||||||||||||||||||||||||||
储存：室温 状态：白色到灰白色粉末或晶体或结晶块状或颗粒或片状 | |||||||||||||||||||||||||||||||||||
| SML1909 | Sigma-Aldrich | RS 23597-190 | ≥98% (HPLC) | 1117.23元/5 MG; | 咨询 | ||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2). 基本信息
产品性质
安全信息
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