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CAS: 149676-40-4
分子式: C18H28FN3O8S
分子量: 465.49
熔点: 271°C
中文名称: 
甲磺酸培氟沙星二水合物
英文名称: 
pefloxacin mesylate dihydrate
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货号品牌产品名称规格包装、参考价格
P815514MACKLIN培氟沙星99%35元/1g;   100元/5g;   498元/25g;   咨询
储存:2~8°C
状态:白色到浅黄色粉末
P796910MACKLIN培氟沙星10mM in DMSO932元/1ml;   咨询
储存:-20°C
467825J&KPefloxacin mesylate dihydrate98%671元/100MG;   咨询

基本信息

分子式C17H20FN3O3·CH4O3S·2H2O
分子量465.49
熔点271
沸点529
闪点110
MDL编码MFCD01685696
Merck14,7066
EINECS 编号274-613-9
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Warning
危险说明H319
防范说明P305+P351+P338
WGK3
RTECSVB2002200
TSCA
P0309000Pefloxacin mesilate dihydrateEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

包装

Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

线性分子式C17H20FN3O3 • CH4O3S • 2H2O
分子量465.49
MDL编号MFCD01685696
PubChem化学物质编号329820029
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringO.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
InChI1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
InChI keyLEULAXMUNMRLPW-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H319
预防措施声明P264 - P280 - P305 + P351 + P338 - P337 + P313
危险分类Eye Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
P0106Sigma-AldrichPefloxacin mesylate dihydrate420.97元/10 G;   咨询

产品说明

一般描述

Chemical structure: fluoroquinolone

应用

Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes.

包装

10, 50 g in poly bottle

生化/生理作用

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

基本信息

线性分子式C17H20FN3O3 • CH4O3S • 2H2O
分子量465.49
EC 号274-613-9
MDL编号MFCD01685696
PubChem化学物质编号329820015

产品性质

质量水平100
溶解性H2O: 50 mg/mL
作用机制DNA synthesis | interferes
enzyme | inhibits
抗生素抗菌谱Gram-negative bacteria
Gram-positive bacteria
储存温度2-8℃
SMILES stringO.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
InChI1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
InChI keyLEULAXMUNMRLPW-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H319
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
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