CAS 149092-50-2; tyrphostin ag 825

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产品名称

规格

包装、参考价格

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B726623

MACKLIN

3-(3-((苯并[d]噻唑-2-基硫代)甲基)-4-羟基-5-甲氧基苯基)-2-氰基丙烯酰胺

99%

746元/25mg; 1266元/50mg; 2152元/100mg;

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储存：-20°C, 干燥

T5443

Sigma-Aldrich

Tyrphostin AG 825

≥92.5%

1509.18元/2 MG;

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产品说明

应用

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

生化/生理作用

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².
EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

制备说明

Tyrphostin AG 825 is soluble in DMSO and methanol.

基本信息

经验(实验)分子式	C₁₉H₁₅N₃O₃S₂
分子量	397.47
MDL编号	MFCD01074971
PubChem化学物质编号	329826823
NACRES	NA.77

产品性质

质量水平	200
测定	≥92.5%
形式	powder
溶解性	DMSO: soluble methanol: soluble
储存温度	−20℃
SMILES string	COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
InChI	1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
InChI key	KXDONFLNGBQLTN-WUXMJOGZSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

121765

Sigma-Aldrich

AG 825-CAS 149092-50-2-Calbiochem

A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC₅₀ = 0.35 µM) relative to HER1 (IC₅₀= 19 µM) autopho

2165.23元/2 MG;

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产品说明

一般描述

A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC₅₀ = 0.35 µM) relative to HER1 (IC₅₀= 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185^neu.
A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC₅₀ = 0.35 µM) relative to HER-1 (IC₅₀ = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185^neu.

包装

2 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target IC₅₀: 0.35 µM against HER2
Product does not compete with ATP.
Primary Target
HER2
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.

其他说明

Ashton, J.M., et al. 2012. Cell Stem Cell11, 359.
Tsai, C.M., et al. 1996. Cancer Res.56, 1068.
Levitzki, A., and Gazit, A. 1995. Science267, 1782.
Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₉H₁₅N₃O₃S₂
分子量	397.47
MDL编号	MFCD01074971

产品性质

质量水平	100
测定	≥94% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable