CAS 147388-83-8; abt-418 盐酸盐; abt-418 hydrochloride

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CAS:

147388-83-8

分子式:

C₉H₁₅ClN₂O

分子量:

202.68

中文名称:

abt-418 盐酸盐

英文名称:

abt-418 hydrochloride

3-methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

M982270

MACKLIN

3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐

99%

1513元/5mg; 5050元/25mg;

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储存：2-8°C, 密封, 干燥

A6476

Sigma-Aldrich

ABT-418 hydrochloride

powder, ≥98% (HPLC)

2741.02元/5 MG; 9449元/25 MG;

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产品说明

一般描述

ABT-418 is an α4β2 agonist of nicotinic receptors.

应用

ABT-418 hydrochloride has been used as a nicotinic acetylcholine receptor (nAChR) agonist to test its effect on spatial memory improvement in attention deficit hyperactivity disorder (ADHD) rat model
ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer′s disease.

包装

5, 25 mg in glass bottle

生化/生理作用

Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.

特点和优势

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.

基本信息

经验(实验)分子式	C₉H₁₄N₂O · HCl
分子量	202.68
MDL编号	MFCD11045960
PubChem化学物质编号	24724395
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
溶解性	H₂O: soluble 15 mg/mL
创始人	Abbott
SMILES string	Cl.CN1CCC[C@H]1c2cc(C)no2
InChI	1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1
InChI key	VOXHERKWAIEJQF-QRPNPIFTSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H300 + H310 + H330
预防措施声明	P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
危险分类	Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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