| CAS: | 1472624-85-3 | |
| 分子式: | C18H15NO4 | |
| 分子量: | 309.32 | |
| 英文名称: |
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| 用途: | 7ACC2是MCT高效抑制剂，对[14C]-乳酸流入抑制的IC50值为11nM，是针对癌细胞乳酸转运的新型抗肿瘤分子。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||
| A882238 | MACKLIN | 7ACC2 | 99% | 954元/2mg; 1305元/5mg; 3820元/25mg; | 咨询 | ||||||||||||||||||||||||||||||
储存：2-8℃ 状态：白色到米黄色到浅黄色到黄色粉末或固体 | |||||||||||||||||||||||||||||||||||
| A792633 | MACKLIN | 7ACC2 | 10mM in DMSO | 646元/1ml; | 咨询 | ||||||||||||||||||||||||||||||
储存：-20°C, 避光 | |||||||||||||||||||||||||||||||||||
| SML3106 | Sigma-Aldrich | 7ACC2 | ≥98% (HPLC) | 975.89元/5 MG; 3157.38元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||
产品说明 生化/生理作用 7ACC2 is a monocarboxylate transporters MCT1 & MCT4 (SLC16A1 & SLC16A3) inhibitor that affects lactate uptake-dependent cancer growth in cultures (uptake/proliferation IC50 = 59/220 nM; MCT1/4-expressing SiHA cervix cancer in the absence of glucose) and in vivo (3 mg/kg/day i.p.; SiHa, HCT116, MCF-7 in mice), without affecting lactate efflux or the survival of highly glycolytic HL-60 (MCT1) or MDA-MB231 (MCT4) cancer cells. Unlike the MCT1/2 inhibitor AR-C155858, 7ACC2 does not block MCT1-mediated uptake of the anti-cancer drug 3-bromopyruvate (3-BP). 基本信息
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安全信息
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