CAS 1462249-75-7; pfk-158

CAS:

1462249-75-7

分子式:

C₁₈H₁₁F₃N₂O

分子量:

328.29

英文名称:

pfk-158

pfk 158

(2e)-1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one

(e)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one

pfk158

用途:

PFK-158是一种有效的选择性PFKFB3抑制剂，目前对晚期实体瘤研究处于临床一期阶段。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

P882268

MACKLIN

PFK-158

≥98%

639元/10mg; 1918元/50mg;

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储存：2-8℃

P797686

MACKLIN

PFK-158

10mM in DMSO

520元/1ml;

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储存：-20°C

SML3145

Sigma-Aldrich

PFK-158

≥98% (HPLC)

975.89元/5 MG; 3157.38元/25 MG;

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产品说明

生化/生理作用

PFK158 is a 3PO analog with improved PFKFB3 inhibitory potency (cell-free IC50 = 137 nM; Jurkat cellular IC50 = 1.62 μM/PFKFB3 activity, 847 nM/2-deoxyglucose uptake, 328 nM/toxicity) and pharmacokinetic properties. PFK158 markedly sensitizes BRAF(V600E)-positive A375 melanoma cells to apoptosis induction by vemurafenib in cultures and causes ~80% growth inhibition in several murine models of human-derived tumors in vivo (60 mg/kg qod. ip.).

基本信息

经验(实验)分子式	C₁₈H₁₁F₃N₂O
分子量	328.29
MDL编号	MFCD28386154

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	O=C(/C=C/C1=NC2=C(C=CC(C(F)(F)F)=C2)C=C1)C3=CC=NC=C3

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable