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CAS: 144875-48-9
分子式: C17H22N4O2
分子量: 314.39
熔点: 193°C(lit.)
中文名称: 
雷西莫特
4-氨基-2-(乙氧基甲基)-α
α-二甲基-1h-咪唑并(4,5-c)喹啉-1-乙醇
英文名称: 
resiquimod
4-amino-2-(ethoxymethyl)-alpha
alpha-dimethyl-1h-imidazo(4,5-c)quinoline-1-ethanol
r848
r-848
s28463
推荐供应商
货号品牌产品名称规格包装、参考价格详情
R766720MACKLIN雷西莫特10mM in DMSO480元/1ml;   展开
储存:-20°C, 干燥
R868373MACKLIN雷西莫特98%179元/25mg;   521元/100mg;   1224元/500mg;   2150元/1g;   8800元/5g;   展开
储存:-20°C
状态:白色到棕褐色固体
R0197TCIResiquimod>98.0%(HPLC)730元/25MG;   2290元/100MG;   展开

基本信息

纯度/分析方法>98.0%(HPLC)
分子式/分子量C17H22N4O2 = 314.39
外观与形状(20℃)固体
储存温度-20℃
储存在惰性气体下存放于惰性气体之中
应避免的情况湿气 (吸湿),加热
Reaxys-RN9792901
PubChem物质ID354335079
Merck Index (14)8151
MDL编号MFCD00937759

技术规格

AppearanceWhite to Light yellow to Light orange powder to crystal
Purity(HPLC)min. 98.0 area%

物性(参考值)

熔点193 ℃
最大吸收波长325 nm

相关法规

RTECS#NJ5911320
1499059J&KResiquimod98%658元/25MG;   1988元/100MG;   展开

基本信息

分子式C17H22N4O2
分子量314.38
熔点193
MDL编码MFCD00937759
Beilstein9792901
Merck14,8151
存储条件Freezer -20℃

安全信息

RTECSNJ5911320
SML0196Sigma-AldrichResiquimod≥98% (HPLC)1476.5元/10 MG;   5967.61元/50 MG;   展开

产品说明

应用

瑞喹莫德已用于刺激骨髓源性树突状细胞(BMDC)(和B细胞。它也被用作恶性黑色素瘤细胞系B16F10中Toll样受体(TLR7)的配体。
雷西莫特可用于免疫学和癌症相关的细胞信号传导研究。

包装

10, 50 mg in glass bottle

生化/生理作用

雷西莫特(R-848)是一种有效的TLR7/TLR8合成激动剂,具有抗病毒和抗肿瘤活性。
雷西莫特属于咪唑喹啉胺类化合物,具有免疫调节作用。雷西莫特可提高细胞因子的水平,如TNF-α、IL-6和IFN-α。
瑞喹莫德是314.4 Da分子,可在 L. infantum Sp内脏感染期间引发免疫功能。它可以介导粒细胞、巨噬细胞、白细胞和树突状细胞的运输。它是治疗皮肤肿瘤的建议外敷药物,例如光化性角化病(AK)和表浅性基底细胞癌。

特点和优势

《受体分类和信号转导》手册的 细胞因子受体(白细胞介素-1受体/TIR家族) 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处。

基本信息

经验(实验)分子式C17H22N4O2
分子量314.38
MDL编号MFCD00937759
PubChem化学物质编号329825221
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
储存条件desiccated
protect from light
颜色 white to tan
溶解性DMSO: 10 mg/mL, clear (warmed to 60 ℃)
运输wet ice
储存温度−20℃
SMILES stringCCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
InChI1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
InChI keyBXNMTOQRYBFHNZ-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
223896Fluorochem1-(4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol95%5302元/250mg;   13750元/1g;   47586元/5g;   展开

基本信息

CAS Number144875-48-9
MDL NumberMFCD00937759

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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