| CAS: | 144675-97-8 | |
| 分子式: | C17H19N5O2·2C4H4O4 | |
| 分子量: | 557.51 | |
| 中文名称: |
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| 英文名称: |
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| 用途: | Pixantrone是一种新型的aza-anthracenedione化合物，具有抗肿瘤活性。它对topoisomerase II具有弱抑制活性，通过对DNA超甲基化位点烷基化，形成DNA加合物。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||||||
| B873138 | MACKLIN | Pixantrone dimaleate | 99% | 387元/5mg; 1991元/50mg; 2835元/100mg; | 展开 | ||||||||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：粉末 | |||||||||||||||||||||||||||||||||||||||||||||||
| B793316 | MACKLIN | Pixantrone dimaleate | 10mM in DMSO | 648元/1ml; | 展开 | ||||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||||
| C46552 | Alfa Aesar | Pixantrone dimaleate | 7944元/250mg; | 展开 | |||||||||||||||||||||||||||||||||||||||||||
基本信息 Ref# 分子式 分子量 GHS危害和防范说明 GHS符号 Hazard Statements | |||||||||||||||||||||||||||||||||||||||||||||||
| SML2577 | Sigma-Aldrich | Pixantrone dimaleate | ≥98% (HPLC) | 928.71元/5 MG; 3747.22元/25 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 Pixantrone (BBR 2778) is an aza-anthracenedione with enhanced antitumor activity due to its DNA-intercalating and topoisomerase II-poisoning activity. Pixantrone shows no signs of acute or delayed cardiotoxicity seen with anthracyclines mitoxantrone and doxorubicin (DOX), while exhibiting comparable in vivo efficacy against solid tumors in mice. Tests conducted on human myocardial strips ex vivo shows that not only pixantrone does not form superoxide anion and hydrogen peroxide (O2•− and H2O2) seen with DOX due to redox activation, pixantrone and its metabolites, especially N-dealkylated, show competitive inhibition against DOX reduction. While mitoxantrone does not form O2•− and H2O2 on its own, it synergizes with DOX to form more O2•− and H2O2, whose formation and subsequent production of the long-lived metabolite doxorubicinol contribute to DOX cardiotoxicity. 基本信息
产品性质
安全信息
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