CAS 143692-48-2; 7h-1,3-dioxolo(4,5-h)(2,3)benzodiazepine-7-carboxamide, 8,9-dihydro-5-(4-aminop

CAS:

143692-48-2

分子式:

C₁₉H₂₁ClN₄O₃

分子量:

388.85

英文名称:

7h-1,3-dioxolo(4,5-h)(2,3)benzodiazepine-7-carboxamide, 8,9-dihydro-5-(4-aminop

8- dimethyl-henyl)- monohydrochloride

gyki 53655

3-dioxolo(4,5-h)(2,3)benzodiazepine-7-carboxamide,8,9-dihydro-5-(4-aminophenyl)-n,8- dimethyl-7h- monohydrochloride

用途:

GYKI53655 hydrochloride 是 α-氨基-3-羟基-5-甲基异恶唑-4-丙酸 (AMPA) 的拮抗剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

G882418

MACKLIN

GYKI53655 hydrochloride

≥99%

499元/1mg; 1198元/5mg;

咨询

储存：2-8℃

G7798

Sigma-Aldrich

GYKI-53655 hydrate

>99.0% (HPLC)

3218.16元/5 MG; 10258.6元/25 MG;

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产品说明

应用

GYKI-53655 hydrate has been used as a calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) receptor antagonist in single-particle tracking experiments.

包装

5, 25 mg in glass bottle

生化/生理作用

GYKI-53655 also inhibits the kainate GluK3 homomeric and GluK2/3 heteromeric receptors. It exhibits anti-ischemic, anti-convulsant, and acute neuroprotective activity.
GYKI-53655 is an AMPA antagonist and noncompetitive negative allosteric modulator.

特点和优势

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₉H₂₀N₄O₃ · HCl · xH₂O
分子量	388.85 (anhydrous basis)

产品性质

质量水平	100
测定	>99.0% (HPLC)
形式	powder
颜色	yellow to orange
溶解性	H₂O: >10 mg/mL
储存温度	2-8℃

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable