CAS 143457-40-3; n-(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-l-naphthylalanyl-l-alanine amide, tnf-α protease inhibitor-0; tapi-0-cas 143457-40-3-calbiochem

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货号

品牌

产品名称

规格

包装、参考价格

详情

579050

Sigma-Aldrich

TAPI-0-CAS 143457-40-3-Calbiochem

TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM).

6319.29元/1 MG;

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产品说明

一般描述

A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.
A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC₅₀ = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC₅₀: 100 nM against TACE (TNF-α converting enzyme/ADAM17)
Primary Target
TNF-α converting enzyme/ADAM17
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Mullberg, J., et al. 1995. J. Immunol.155, 5198.
Mohler, K.M., et al. 1994. Nature370, 218.

法律信息

Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₄H₃₂N₄O₅
分子量	456.53

产品性质

质量水平	100
测定	≥96% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	white
溶解性	50% acetic acid: 1 mg/mL DMSO: 5 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1
InChI key	CRCPLBFLOSEABN-VBSNWNEZSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable