CAS 142227-49-4; 4′-hydroxy carvedilol; 4-(2-(3-(9h-carbazol-4-yloxy)-2-hydroxypropylamino)ethoxy)-3-methoxyphenol

CAS:

142227-49-4

分子式:

C₂₄H₂₆N₂O₅

分子量:

422.47

中文名称:

4′-hydroxy carvedilol

4′-oh carvedilol

4′-hydroxyphenyl carvedilol

4′oh-cvd

英文名称:

4-(2-(3-(9h-carbazol-4-yloxy)-2-hydroxypropylamino)ethoxy)-3-methoxyphenol

bm 14686

4-[2-[[3-(9h-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol

carvedilol metabolite m4

bm 140686

4ohc

用途:

4-Hydroxyphenyl Carvedilol是Carvedilol的代谢物。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

C882568

MACKLIN

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol

98%

1680元/2mg; 2624元/5mg;

咨询

储存：2-8℃

SMB00928

Sigma-Aldrich

4′-Hydroxy carvedilol

864.63元/1 MG; 3458.67元/5 MG;

咨询

产品说明

一般描述

Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.

应用

Metabolomics

基本信息

经验(实验)分子式	C₂₄H₂₆N₂O₅
分子量	422.47

产品性质

质量水平	100
测定	≥95%
形式	solid
颜色	off-white to white
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3