CAS 141992-47-4; cdk4 inhibitor ii, nsc 625987-cas 141992-47-4-calbiochem

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CAS:

141992-47-4

分子式:

C₁₅H₁₃NO₂S

分子量:

271.33

英文名称:

cdk4 inhibitor ii, nsc 625987-cas 141992-47-4-calbiochem

1,4-dimethoxyacridine-9(10h)-thione

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

N937688

MACKLIN

NSC 625987

≥98%

1680元/5mg; 5250元/25mg; 13050元/100mg;

咨询

储存：2-8°C，密封，干燥

219477

Sigma-Aldrich

Cdk4 Inhibitor II, NSC 625987-CAS 141992-47-4-Calbiochem

The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor

2671.25元/5 MG;

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产品说明

一般描述

A potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC₅₀ >100 µM).
A thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC₅₀ >100 µM).

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
CDK4/D1
Target IC₅₀: 200 nM against CDK4/D1
Product does not compete with ATP.
Cell permeable: no
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Kubo, A., et al. 1999. Clin. Cancer Res.5, 4279.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₅H₁₃NO₂S
分子量	271.33
MDL编号	MFCD08276925

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	brown
溶解性	ethanol: 2.5 mg/mL DMSO: 25 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)
InChI key	KFAKESMKRPNZTM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

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