CAS 1404-93-9; 万古霉素; vancomycin,hydrochloride

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产品名称

规格

包装、参考价格

V820413

MACKLIN

盐酸万古霉素

USP,potency: ≥900μg/mg

150元/500mg; 255元/1g; 750元/5g; 1850元/25g; 3998元/100g; 12000元/500g;

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储存：2~8°C
状态：白色到灰白色到棕色粉末
万古霉素(vancomycin)是来自东方链霉菌(streptomyceso-rientalis)或土壤丝菌属(Amycolatipsisorientalis)的糖肽类抗生素，具有独特的三重抗菌机制：抑制细菌细胞壁的蛋白质合成，改变细菌细胞膜的通透性，阻碍细菌RNA的合成。广泛应用于耐甲氧西林金黄色葡萄球菌(MRSA)和其他革兰阳性菌感染。

V6062

MACKLIN

万古霉素盐酸盐

生物技术级

336元/1g; 1010元/5g;

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储存：2~8°C
状态：白色到橙棕色粉末
万古霉素(vancomycin)是来自东方链霉菌(streptomyceso-rientalis)或土壤丝菌属(Amycolatipsisorientalis)的糖肽类抗生素，具有独特的三重抗菌机制：抑制细菌细胞壁的蛋白质合成，改变细菌细胞膜的通透性，阻碍细菌RNA的合成。广泛应用于耐甲氧西林金黄色葡萄球菌(MRSA)和其他革兰阳性菌感染。

122263

J&K

Vancomycin hydrochloride, from Streptomyces orientalis, ≥900 μg/mg

来源于东方链霉菌, ≥900 微克/毫克

517元/1G; 2056元/5G;

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基本信息

分子式	C₆₆H₇₅Cl₂N₉O₂₄·HCl
分子量	1485.71
MDL编码	MFCD03613611
Beilstein	3704657
Merck	14,9929
存储条件	Store at 2-8℃

安全信息

图形或危害标志
提示语	Warning
危险说明	H317
防范说明	P280
WGK	2
RTECS	YW4380000
TSCA	否

BP2958-1

Alfa Aesar

Vancomycin hydrochloride

2817元/1g;

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基本信息

Ref#
F54347

V2002

Sigma-Aldrich

Vancomycin hydrochloride from Streptomyces orientalis

≥900 μg per mg (as vancomycin base)

732.84元/100 MG; 1611.29元/250 MG; 5427.88元/1 G; 18343.6元/5 G;

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产品说明

一般描述

化学结构：糖肽

应用

来自东方链霉菌的万古霉素用于治疗由耐甲氧西林(β-内酰胺抗性)葡萄球菌的易感菌株而引起的严重或急性感染。它用于在肽聚糖生物合成水平阻断细菌细胞壁生物合成。它被广泛用于癌症患者。. 万古霉素的过度使用已被研究，从而得到了推荐的指南。

包装

1, 5 g in glass bottle
100, 250 mg in glass bottle
无底玻璃瓶。内含物装在插入的融合锥内。

生化/生理作用

万古霉素是一种可在肽聚糖生物合成水平阻断细菌细胞壁生物合成的糖肽抗生素。它会抑制NAM/NAG-肽的末端D-丙氨酰-D-丙氨酸部分插入。它可有效用于革兰氏阳性菌。万古霉素可改变细菌细胞膜的通透性和RNA合成。
糖肽抗生素
作用模式：用于通过抑制NAM/NAG-肽的末端D-丙氨酰-D-丙氨酸部分的插入在肽聚糖生物合成水平阻断细菌细胞壁生物合成。
抗菌谱：革兰氏阳性菌

其他说明

保持容器密闭并置于干燥通风处。

基本信息

经验(实验)分子式	C₆₆H₇₅Cl₂N₉O₂₄ · HCl
分子量	1485.71
Beilstein	3704657
PubChem化学物质编号	24900723
NACRES	NA.85

产品性质

质量水平	200
生物来源	Streptomyces orientalis
测定	≥900 μg/mg ( as vancomycin base )
形式	powder
储存条件	(Keep container tightly closed in a dry and well-ventilated place.)
颜色	off-white to brown
抗生素抗菌谱	Gram-positive bacteria
作用机制	cell wall synthesis \| interferes
储存温度	2-8℃
SMILES string	Cl[H].CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]2C[C@](C)(N)[C@@H](O)[C@@H](C)O2.CN[C@H](CC(C)C)C(=O)NC3[C@H](O)c4ccc(Oc5cc6Oc7ccc(cc7Cl)[C@@H](O)[C@H]8NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC3=O)c(c5)c6)c9ccc(O)c(c9)-c%10c(O)cc(O)cc%10[C@@H](NC8=O)C(O)=O)c(Cl)c4

安全信息

象形图
警示用语：	Danger
危险声明	H317 - H334
预防措施声明	P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
危险分类	Resp. Sens. 1 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves

SBR00001

Sigma-Aldrich

Vancomycin hydrochloride

Ready Made Solution, 100 mg/mL in DMSO

784.22元/10 ML;

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产品说明

一般描述

Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis. It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.

应用

Vancomycin hydrochloride may be used-

for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions
for the estimation of biomass in a culture of various strains of bacteria
as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.

生化/生理作用

Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP-N-acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme. It is a frequently used antibiotic for the treatment of peritonitis caused by gram-positive bacteria in patients with continuous ambulatory peritoneal dialysis. In patients with cirrhosis, it is used to control portal systemic encephalopathy. Mice with Clostridium difficile infection (CDI) had better clinical outcome when treated with vancomycin as opposed to the outcome on treatment with metronidazole.

包装

10ML

其他说明

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

基本信息

经验(实验)分子式	C₆₆H₇₅Cl₂N₉O₂₄ · xHCl
分子量	1449.25 (free base basis)
NACRES	NA.85

产品性质

质量水平	200
生物来源	Streptomyces orientalis
形式	liquid
储存条件	(Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
浓度	100 mg/mL in DMSO
颜色	colorless to faint tan
作用机制	cell wall synthesis \| interferes
抗生素抗菌谱	Gram-positive bacteria
储存温度	−20℃

安全信息

象形图
警示用语：	Danger
危险声明	H317 - H334
预防措施声明	P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
危险分类	Resp. Sens. 1 - Skin Sens. 1
储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	188.6 °F - closed cup
闪点(C)	87 ℃ - closed cup