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CAS: 14028-44-5
分子式: C17H16ClN3O
分子量: 313.79
中文名称: 
氯氧平
氯哌氧草
阿莫沙平
英文名称: 
2-Chloro-11(1-Piperazinyl)dibenz [b,f] [1,4]oxazepine
f)(1,4)oxazepine, 2-chloro-11-(1-piperazinyl)-dibenz(
2-chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine
amoxan
amoxapine
asendin
cl 67772
demolox
moxadil
性质描述: 熔点313.5℃。
生产方法: 氯甲酸乙酯和邻-(对氯苯氧基)苯胺盐酸盐反应制取邻-(对氯苯氧基)苯氨基甲酸乙酯,再使其与N-乙酯基哌嗪反应,生成4-[[邻-(对氯苯氧基)苯基]氨基甲酰]-1-哌嗪羧酸乙酯,将此哌嗪羧酸酯和五氧化二磷、三氯氧磷一起加热回流,环合得到氯氧平。
用途: 抗忧郁药。
推荐供应商
货号品牌产品名称规格包装、参考价格
A2499TCIAmoxapine>97.0%(GC)(T)1035元/1G;   3450元/5G;   咨询

基本信息

纯度/分析方法>97.0%(GC)(T)
分子式/分子量C17H16ClN3O = 313.79
外观与形状(20℃)固体
包装和容器 1G-带有塑料内管的玻璃瓶 (查看图片)
PubChem物质ID181085854
Merck Index (14)576
MDL编号MFCD00069210

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(GC)min. 97.0 %
Purity(Nonaqueous Titration)min. 97.0 %
Melting point178.0 to 182.0 ℃

物性(参考值)

熔点179 ℃

安全信息

图形或危害标志
信号词危险
危险性说明H302 : 吞咽有害。
H370 : 会损害器官。
H341 : 怀疑可造成遗传性缺陷。
H413 : 可能对水生生物造成长期持续有害影响。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P273 : 避免释放到环境中。
P260 : 不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸气/ 喷雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308+P311 : 如接触到或有疑虑:呼叫急救中心/医生。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#HQ4025500
A129Sigma-AldrichAmoxapine650.91元/100 MG;   1931.43元/500 MG;   9171.43元/5 G;   咨询

产品说明

应用

Amoxapine has been used as an antidepressant drug to test its effect on locomotion and egg release in response to gain-of-functional mutations in potassium (K+) channels (unc-58) of C. elegans. It has also been used as an antipsychotic drug to test its effect on the viability of glioblastoma cells.

生化/生理作用

Amoxapine, a structural analog of clozapine, is a human ether a-go-go (hERG) channel blocker. It is also an N-methylated metabolite of loxapine. It is a tricyclic antidepressant that inhibits the uptake of norepinephrine and blocks 5- hydroxytryptamine (HT2 ) serotonergic receptors.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A129.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式C17H16ClN3O
分子量313.78
EC 号237-867-1
MDL编号MFCD00069210
PubChem化学物质编号24278075
NACRESNA.77

产品性质

质量水平100
溶解性methanol: soluble
创始人Wyeth
SMILES stringClc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1
InChI1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChI keyQWGDMFLQWFTERH-UHFFFAOYSA-N
Gene Informationhuman ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
1031401USPAmoxapineUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C17H16ClN3O
分子量313.78
MDL编号MFCD00069210
PubChem化学物质编号329749017

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringClc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1
InChI1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChI keyQWGDMFLQWFTERH-UHFFFAOYSA-N
Gene Informationhuman ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), SLC6A2(6530), SLC6A4(6532)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHR1841SupelcoAmoxapinePharmaceutical Secondary Standard; Certified Reference Material2252.27元/500 MG;   咨询

产品说明

一般描述

Amoxapine is a tricyclic antidepressant known to inhibit reuptake of neuronal transmitter. The drug helps in controlling agitation and anxiety along with depression.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Amoxapine may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by ultraviolet-spectrophotometric method.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB2753 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C17H16ClN3O
分子量313.78
EC 号237-867-1
MDL编号MFCD00069210

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
application(s)pharmaceutical
格式neat
药典可追溯性traceable to USP 1031401
储存温度2-30℃
SMILES stringClc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1
InChI1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChI keyQWGDMFLQWFTERH-UHFFFAOYSA-N
Gene Informationhuman ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), SLC6A2(6530), SLC6A4(6532)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
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