产品说明

一般描述

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

外形

Lyophilized from 0.2 μm-filtered solution in PBS.

重悬

Reconstitute with 100 μL deionized water.

其他说明

Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG^®-tag.

法律信息

FLAG is a registered trademark of sigma-aldrich Co. LLC

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产品性质

安全信息