CAS 138-14-7; propionohydroxamic acid, n-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido)

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产品名称

规格

包装、参考价格

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D875507

MACKLIN

甲磺酸去铁胺

≥92.5%

128元/25mg; 358元/100mg; 966元/500mg;

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储存：-20℃
状态：白色到灰白色粉末

D873692

MACKLIN

甲磺酸去铁胺

≥98%

58元/5mg; 185元/25mg; 395元/100mg; 1110元/500mg; 1619元/1g; 6599元/5g;

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储存：-20℃
状态：白色到灰白色固体

454081

J&K

Deferoxamine mesylate salt

97%

465元/250MG; 1559元/1G; 5456元/5G;

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基本信息

分子式	C₂₆H₅₂N₆O₁₁S
分子量	656.79
熔点	145-149
MDL编码	MFCD00058605
Beilstein	4122177
EINECS 编号	205-314-3
存储条件	Freezer -20℃

安全信息

防范说明	P262
WGK	2
RTECS	UG5310000

C46177

Alfa Aesar

Deferoxamine mesylate

95%

4104元/1g;

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基本信息

Ref#
46177

分子式
C25H48N6O8.CH4O3S

分子量
292.13

252750

Millipore

Deferoxamine Mesylate-CAS 138-14-7-Calbiochem

Parenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload.

1877.44元/1 G;

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产品说明

一般描述

Parenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows anti-proliferative effect on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.
Parenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows antiproliferative effects on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic moieties with trans-peroxynitrous acid.

包装

1 g in Plastic ampoule

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

其他说明

Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
Dzwigaj, S., and pererat, H., 1995. Free Radic. Res.14, 103.
Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₅H₄₈N₆O₈ · xCH₄O₃S
分子量	560.68 (free base basis)
MDL编号	MFCD00058605

产品性质

质量水平	100
测定	92.5-100% (TLC)
形式	powder
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
颜色	faint yellow
溶解性	water: 50 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key	IDDIJAWJANBQLJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

D9533

Sigma-Aldrich

Deferoxamine mesylate salt

≥92.5% (TLC), powder

1649.92元/1 g;

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产品说明

生化/生理作用

去铁胺被用作一个缺氧模拟物质去稳定低氧诱导因子1 (HIF-1)。去铁胺通过抑制以HIF-1为靶点的脯氨酰羟化酶(PHDs)降解来稳定HIF-1。去铁胺的抑制机制可能是通过Fe²⁺ 与酶活性所需的PHD活性位点的螯合作用而实现的。
一种铁螯合剂，常用于研究细胞增殖和凋亡。体外和体内实验均显示其对血管平滑肌细胞具有抗增殖作用，并抑制G1期细胞的增殖。据报道，它也诱导p53。通过螯合铁诱导HL-60细胞凋亡。经过1μM去铁胺处理48小时后，DNA明显断裂。细胞经1μM去铁胺处理仅24小时后发生凋亡;48小时后观察到核坍塌。一些研究表明，它具有抗氧化性能，并保护细胞免受H₂O₂诱导的损伤。

基本信息

经验(实验)分子式	C₂₅H₄₈N₆O₈ · CH₄O₃S
分子量	656.79
EC 号	205-314-3
MDL编号	MFCD00058605
PubChem化学物质编号	24894304
NACRES	NA.32

产品性质

质量水平	200
测定	≥92.5% (TLC)
形式	powder
颜色	white to off-white
溶解性	H₂O: 50 mg/mL
储存温度	−20℃
SMILES string	CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI	1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key	IDDIJAWJANBQLJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

D0160000

Deferoxamine mesylate salt

European Pharmacopoeia (EP) Reference Standard

1572.27元/ ;

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产品说明

一般描述

本产品按照发行药典的发行和规定提供。支持本产品的所有信息，包括安全数据表和任何产品信息传单，都是在发行药典的授权下开发和发布的。如需进一步信息和支持，请访问现行药典网站。

生化/生理作用

一种铁螯合剂，常用于研究细胞增殖和凋亡。体外和体内实验均显示其对血管平滑肌细胞具有抗增殖作用，并抑制G1期细胞的增殖。据报道，它也诱导p53。通过螯合铁诱导HL-60细胞凋亡。经过1μM去铁胺处理48小时后，DNA明显断裂。细胞经1μM去铁胺处理仅24小时后发生凋亡;48小时后观察到核坍塌。一些研究表明，它具有抗氧化性能，并保护细胞免受H₂O₂诱导的损伤。

包装

单位数量：30 mg。随时可能改变。产品按照发行药典的规定交付。有关当前单位数量，请访问EDQM对照品目录。

注意

请参见由EDQM提供的SDS。。

其他说明

可能适用相应的销售限制。

基本信息

经验(实验)分子式	C₂₅H₄₈N₆O₈ · CH₄O₃S
分子量	656.79
MDL编号	MFCD00058605
PubChem化学物质编号	329798589
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI	1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key	IDDIJAWJANBQLJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0001934

Deferoxamine for system suitability

European Pharmacopoeia (EP) Reference Standard

1548.8元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

包装

Unit quantity: 15 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₅H₄₈N₆O₈ · CH₄O₃S
分子量	656.79
MDL编号	MFCD00058605
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
格式	neat
储存温度	2-8℃
SMILES string	CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI	1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key	IDDIJAWJANBQLJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

PHR3411

Supelco

Deferoxamine mesylate

certified reference material, pharmaceutical secondary standard

2000.81元/500 mg;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₂₅H₄₈N₆O₈ · CH₄O₃S
分子量	656.79
MDL编号	MFCD00058605

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	pkg of 500 mg
application(s)	pharmaceutical
SMILES string	CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI	1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key	IDDIJAWJANBQLJ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

1166003

USP

Deferoxamine mesylate

United States Pharmacopeia (USP) Reference Standard

3231.47元/300 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₅H₄₈N₆O₈ · CH₄O₃S
分子量	656.79
MDL编号	MFCD00058605
PubChem化学物质编号	329749526
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI	1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key	IDDIJAWJANBQLJ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

BP987

Desferrioxamine mesilate

British Pharmacopoeia (BP) Reference Standard

1916.08元/30 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

包装

Unit quantity: 30 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₅H₄₈N₆O₈ · CH₄O₃S
分子量	656.79
MDL编号	MFCD00058605

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI	1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key	IDDIJAWJANBQLJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable