| CAS: | 136647-02-4 | ||
| 分子式: | C29H36ClNO2 | ||
| 分子量: | 466.05 | ||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| D978070 | MACKLIN | 4-(苯甲酰氧基甲基)-1-[3-(4-甲氧基苯基)丙基]哌啶; 盐酸盐 | 95% | 3490元/10mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Y10191 | Alfa Aesar | UK-78,282 (hydrochloride) | 23535元/100mg; 37918元/250mg; 0元/1g; | 咨询 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
基本信息 分子量 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| U3885 | Sigma-Aldrich | UK-78282 monohydrochloride | ≥98% (HPLC) | 1700.13元/5 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function. 特点和优势 This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. 制备说明 UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml. 基本信息
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安全信息
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