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CAS: 136434-34-9
分子式: C18H20ClNOS
分子量: 333.88
熔点: 118-122°C
中文名称: 
盐酸度洛西汀
(S)-(+)-n-甲基-3(1-萘基氧基)-3-(2-噻吩基)丙酰胺盐酸盐
英文名称: 
duloxetine hydrochloride
(S)-(+)-n-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride
推荐供应商
货号品牌产品名称规格包装、参考价格详情
D795312MACKLIN盐酸度洛西汀10mM in DMSO362元/1ml;   展开
储存:-20°C
D808419MACKLIN盐酸度洛西汀≥98.0%(HPLC)33元/200mg;   76元/1g;   192元/5g;   616元/25g;   2021元/100g;   展开
储存:-20°C
状态:白色到米黄色粉末
D4223TCIDuloxetine Hydrochloride>98.0%(T)(HPLC)80元/1G;   190元/5G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C18H19NOS・HCl = 333.87
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
包装和容器 1G-带有塑料内管的玻璃瓶 (查看图片)
相关CAS RN116539-59-4
Reaxys-RN8168890
PubChem物质ID160871378
Merck Index (14)3465
MDL编号MFCD06407958

技术规格

AppearanceWhite to Light yellow to Light orange powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Melting point161.0 to 165.0 ℃
Specific rotation [a]20/D+120 to +124 deg(C=1, MeOH)

物性(参考值)

熔点164 ℃
比旋光度 [α]D122° (C=1,MeOH)
溶解性(可溶于)甲醇

安全信息

图形或危害标志
信号词警告
危险性说明H361 : 怀疑对生育能力或胎儿造成伤害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑:求医/就诊。
P405 : 存放处须加锁。

相关法规

RTECS#XN0258000
365552J&KDuloxetine Hydrochloride99%, 是5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),Ki为 4.6 nM808元/1G;   2613元/5G;   展开

基本信息

分子式C18H19NOS·HCl
分子量333.88
熔点161-165
比旋光度([α]20D)115.5° to 124.5° (C=1, MeOH)
MDL编码MFCD06407958
BeilsteinN/A 8168890
存储条件Freezer -20℃

产品描述

Duloxetine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂,Ki为4.6 nM,用于治疗重度抑郁症和广泛性焦虑症(GAD)。

靶点(IC50 & Targe)

DA transporter

Noradrenaline transporter (Sodium-dependent)

ert (Sodium-dependent)

参考文献

[1] Wong DT, et al. Life Sci, 1988, 43(24):2049-57.

安全信息

图形或危害标志
提示语Warning
危险说明H302
H410
防范说明P264
P270
P273
P301+P312
P501
UN号码3077
危险分类9
包装等级III
RTECSXN0258000
C46314Alfa AesarDuloxetine Hydrochloride1574元/1g;   6200元/5g;   展开

基本信息

Ref#
46314

分子式
C18H19NOS.HCl

分子量
482.44

GHS危害和防范说明

GHS符号

Hazard Statements
H361
Suspected of damaging fertility or the unborn child.

Precautionary Statements
P201 P280 P308+P313

Y0001454Duloxetine for system suitabilityEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

盐酸度洛西汀是一种双重血清素/去甲肾上腺素再摄取抑制剂(SNRI),在临床上被广泛用作抗抑郁药和抗焦虑药。

包装

Unit quantity: 40 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C18H19NOS · HCl
分子量333.88
MDL编号MFCD06407958
PubChem化学物质编号329831431
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
InChI1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChI keyBFFSMCNJSOPUAY-LMOVPXPDSA-N
Gene Informationhuman ... SLC6A2(6530), SLC6A4(6532)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0001453Duloxetine HydrochlorideEuropean Pharmacopoeia (EP) Reference Standard1756.05元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

盐酸度洛西汀是一种双重血清素/去甲肾上腺素再摄取抑制剂(SNRI),在临床上被广泛用作抗抑郁药和抗焦虑药。

包装

Unit quantity: 120 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C18H19NOS · HCl
分子量333.88
MDL编号MFCD06407958
PubChem化学物质编号329831430
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
InChI1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChI keyBFFSMCNJSOPUAY-LMOVPXPDSA-N
Gene Informationhuman ... SLC6A2(6530), SLC6A4(6532)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHR1865SupelcoDuloxetine HydrochloridePharmaceutical Secondary Standard; Certified Reference Material3586.98元/500 MG;   展开

产品说明

一般描述

用于质量控制的制药二级标准品,为制药实验室和制造商提供了一种方便且经济的替代方案,可用于内部工作标准品的制备

生化/生理作用

盐酸度洛西汀是一种双重血清素/去甲肾上腺素再摄取抑制剂(SNRI),在临床上被广泛用作抗抑郁药和抗焦虑药。

分析说明

这些二级标准品可追溯至USP、EP和BP一级标准品。

其他说明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。所有关于该 CRM 的信息都可以在分析证书上找到。

附注

要查看该材料的分析证书示例,请在下面的文档栏中输入LRAC1689。这只是一个示例证书,可能不是您收到的批次。

基本信息

经验(实验)分子式C18H19NOS · HCl
分子量333.88
MDL编号MFCD06407958
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
形式powder
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
application(s)pharmaceutical
药典可追溯性traceable to PhEur Y0001453
traceable to USP 1229817
储存温度2-30℃
SMILES stringCl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
InChI1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChI keyBFFSMCNJSOPUAY-LMOVPXPDSA-N
Gene Informationhuman ... SLC6A2(6530), SLC6A4(6532)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1229817USPDuloxetine HydrochlorideUnited States Pharmacopeia (USP) Reference Standard8438.42元/100 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

盐酸度洛西汀是一种双重血清素/去甲肾上腺素再摄取抑制剂(SNRI),在临床上被广泛用作抗抑郁药和抗焦虑药。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C18H19NOS · HCl
分子量333.88
MDL编号MFCD06407958
PubChem化学物质编号329749692
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
InChI1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChI keyBFFSMCNJSOPUAY-LMOVPXPDSA-N
Gene Informationhuman ... SLC6A2(6530), SLC6A4(6532)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
079403Fluorochem(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride95%528元/250mg;   1034元/1g;   3058元/5g;   5082元/10g;   展开

基本信息

CAS Number136434-34-9
MDL NumberMFCD06407958

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H361fd: Reproductive toxicity
防范说明 P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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