| CAS: | 135-23-9 | |||||||||||||||||||||||||||||||
| 分子式: | C14H20ClN3S | |||||||||||||||||||||||||||||||
| 分子量: | 297.85 | |||||||||||||||||||||||||||||||
| 英文名称: |
|
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| M991373 | MACKLIN | 盐酸美沙吡林 | analytical standard | 5220元/1g; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
储存：2-8°C, 密封, 干燥, 避光 状态：固体 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| M-231 | Supelco | Methapyrilene hydrochloride solution | 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant® | 938.76元/1 ML; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 法律信息 CERILLIANT is a registered trademark of Cerilliant Corporation 基本信息
产品性质
安全信息
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 442641 | Supelco | Methapyrilene HCl | analytical standard | 1400.79元/1000 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 Methapyrilene is an H1-receptor antihistamine that is known to cause periportal hepatic necrosis following acute high dose administration to the rat subjects in in vitro studies carried out for the identification of mutagens and/or carcinogens. 应用 Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. 基本信息
产品性质
安全信息
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HY-B1483 | MCE | Methapyrilene hydrochloride,135-23-9_MCE(MedChemExpress) | 267元/10 mM * 1 mL in DMSO; 243元/5 mg; 387元/10 mg; 765元/25 mg; | 咨询 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。 Methapyrilene hydrochlorideMCE 国际站：Methapyrilene hydrochloride 品牌：MedChemExpress (MCE) 货号：HY-B1483 CAS 号：135-23-9 生物活性：盐酸美吡利林（噻吡拉明）是一种口服有效的H1受体抗组胺药，属于吡啶类抗胆碱能药。盐酸美吡利林具有肝毒性，可作为肝毒素在体内引起门静脉周围肝坏死[2]。 体外研究(In Vitro)：Methapyrilene hydrochloride (650 μM) results in a down-regulation of TF and up-regulation of FTL, while the level of HMOX1 is not changed. Additionally, the levels of CD44 and SOX9 proteins and the expression of PROM1 (CD133), hepatic stem cell-associated markers are increased[1].Methapyrilene hydrochloride (650 μM) decreases CYP2E1, CYP3A4, NR1l3, ALB, mRNA expression and increases CD133 expression[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。 体内研究(In Vivo)：Methapyrilene hydrochloride (oral gavage; 40 or 80 mg/kg; 5 days per week; 6 weeks) results in changes in the expression of classic hepatotoxicity-related marker genes and iron homeostasis-related genes, especially a prominent, dose-dependent down-regulation of the transferrin (Tf) gene and an up-regulation of the ferritin, light chain (FTL) gene in rats[1].Methapyrilene hydrochloride (oral gavage; 150 mg/kg; 3 days) causes periportal liver necrosis at high dosage. Methapyrilene is sufficient to induce liver necrosis, or a subtoxic dose of 50 mg/kg/day[2]. MCE尚未独立确认这些方法的准确性。 仅供参考。 分子量：297.85 Formula：C14H20ClN3S 性状：固体 颜色：White to yellow 运输条件：美国大陆地区的室温；其他地区可能有所不同。 储存方式： -20°C，密封保存，避免受潮 *溶剂保存：-80°C，6个月；-20°C，1个月（密封保存，避免受潮） 提供质量检测报告：Data Sheet、SDS、COA、元素分析报告、产品使用指南 产品活性：Methapyrilene (Thenylpyramine) hydrochloride 是一种口服活性 H1 受体 (H1-receptor antihistamine) 抗组胺剂和吡啶类抗胆碱能剂。Methapyrilene hydrochloride 具有肝毒性，可作为肝毒素在体内引起门脉周围肝坏死。 相关产品：ATP (Standard) | Sotorasib (Standard) | ATP | PF-4136309 | Osimertinib (Standard) | Sotorasib | Erastin | BI-2865 | IA-Alkyne | XTT sodium | Macitentan (Standard) | Osimertinib 热门产品线：抑制剂 | 稳定性同位素标记物 | 脂质 | 糖类 Trending products：Inhibitors | Isotope-Labeled Compounds | Lipids | Saccharides MCE 抑制剂: MedChemExpress 信号通路产品覆盖细胞凋亡、自噬、细胞周期与 DNA 损伤、表观遗传、GPCR/G 蛋白、免疫与炎症、JAK/STAT、MAPK/ERK、膜转运体与离子通道、代谢酶与蛋白酶、神经信号、NF-κB、PI3K/Akt/mTOR、PROTAC、蛋白酪氨酸激酶/受体酪氨酸激酶、干细胞/Wnt、TGF-β/Smad 及维生素 D/核受体等研究方向，为肿瘤、感染、炎症与免疫、神经系统疾病、代谢性疾病、心血管疾病和内分泌研究提供多维度的产品选择，助力客户发表文献超 80,000 篇。 相关产品可根据具体情况提供化学结构、作用靶点、生物活性、纯度、溶解度、体内外研究信息、参考文献及质量分析报告 (COA)等资料。 客户发表文献： 参考文献： 品牌介绍:
 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
m.cnreagent.com
