CAS 134-58-7; 8-氮杂鸟嘌呤; 5-Amino-7-hydroxy-1H-triazolo[d] pyrimidine

CAS:

134-58-7

分子式:

C4H4N6O

分子量:

152.12

熔点:

300℃

中文名称:

8-氮杂鸟嘌呤

8-氮鸟嘌呤

5-氨基-1,4-二氢-7H-1,2,3-三唑[4,5-D]嘧啶-7-酮

英文名称:

5-Amino-7-hydroxy-1H-triazolo[d] pyrimidine

5-Amino-1H-triazolo[d]pyrimidin-7-ol

Triazolo analog of guanine

7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-1,4-dihydro-

8-Azaguanine

2,3-Triazolo[4,5-d]pyrimidin-7-one, 5-amino-1,4-dihydro-7H-1

5-d)pyrimidin-7-one, 5-amino-1,6-dihydro-7h-v-triazolo(

5-amino-1,4-dihydro-7h-1,2,3-triazolo(4,5-d)pyrimidin-7-one

5-amino-1,6-dihydro-7h-v-triazolo(4,5-d)pyrimidin-7-one

5-amino-1h-v-triazolo(d)pyrimidin-7-ol

5-amino-7-hydroxy-1h-v-triazolo(d)pyrimidine

3-triazolo(4,5-d)pyrimidin-7-one, 5-amino-1,4-dihydro-7h-2

8 ag

azaguanine

azaguanine-8

azan

azg

b-28

guanazol

guanazolo

nsc-749

pathocidin

pathocidine

sf-337

sk 1150

triazologuanine

5-d)pyrimidin-7-ol, 5-amino-v-triazolo(

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性质描述:

该品为无色结晶体。熔点305℃（分解）。能溶于稀碱和稀酸，几乎不溶于水、醇和醚。

生产方法:

由2,4-二氨基-6-羟基嘧啶经亚硝化、还原、重氮化、环合而得。（1）亚硝化得到2,4-二氨基-5-亚硝基-6-羟基嘧啶：在15℃以下，将亚硝酸钠加至2,4-二氨基-6-羟基嘧啶的水溶液中，滴加浓盐酸，析出玫瑰红色沉淀，pH约为3.5。过滤，水洗至中性，得2,4-二氨基-5-亚硝基-6-羟基嘧啶（亚硝基物）。（2）还原得到2,4,5-三氨基-6-羟基嘧啶硫酸盐（三氨基物）：将亚硝基物混悬于水，搅拌下逐渐投入保险粉。随后加入氢氧化钠溶液，使pH=9，加热至沸，使反应液由红色变为浅黄色。加活性炭脱色，过滤。滤液冷却后，用硫酸调至刚果红呈酸性，析出黄色沉淀。过滤，用乙醇洗涤，得三氨基物。（3）重氮化、环合得8-氮杂鸟嘌呤：将三氨基物悬浮于水中，加氢氧化钠溶液，加热溶解。然后加入亚硝酸钠，搅拌溶解后加冰醋酸。加热至90℃保温反应1h。冷却，过滤，得8-氮杂鸟嘌呤粗品，经精制得成品。

用途:

医药中间体，用于生产抗肿瘤药癌敌-M。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A797832

MACKLIN

8-氮鸟嘌呤

10mM in DMSO

168元/1ml;

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储存：-20°C, 惰性气体
状态：液体

A835352

MACKLIN

8-氮鸟嘌呤

>98%

40元/200mg; 97元/1g; 455元/5g; 2270元/25g;

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储存：2~8 ℃,惰性气体氛围
状态：浅黄色到黄色粉末或晶体

484813

J&K

8-Azaguanine

98%

285元/250mg; 941元/1G;

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基本信息

分子式	C₄H₄N₆O
分子量	152.12
熔点	>300
MDL编码	MFCD00056937
EINECS 编号	205-148-1
存储条件	Freezer -20℃

安全信息

图形或危害标志
提示语	Warning
危险说明	H302
防范说明	P260 P262
WGK	3
RTECS	XZ6157000

Y10177

Alfa Aesar

8-Azaguanine

128元/100mg; 234元/250mg; 450元/1g; 2037元/10g;

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基本信息

分子量
152.11

C22992

Alfa Aesar

8-Azaguanine

1795元/1g; 7358元/5g;

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基本信息

Ref#
22992

分子式
C4H4N6O

分子量
74.14

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P301+P330+P331 P312 P264

219608

Fluorochem

5-Amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one

95%

616元/1g; 1474元/5g; 2596元/10g;

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基本信息

CAS Number	134-58-7
MDL Number	MFCD00056937
Melting Point	>300℃

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.