CAS 133407-86-0; n-cbz-leu-leu-norvalinal

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货号

品牌

产品名称

规格

包装、参考价格

M799351

MACKLIN

B-苄氧羰基-亮氨酸-亮氨酸-正缬氨酸

≥95%

195元/1mg; 622元/5mg;

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储存：2-8°C, 密封, 干燥

C6706

Sigma-Aldrich

Z-Leu-Leu-Norvalinal

≥90% (HPLC), powder

3629.84元/5 MG;

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产品说明

Amino Acid Sequence

Z-Leu-Leu-Nva

包装

1, 5 mg in serum bottle

生化/生理作用

Potent inhibitor of the 20S proteasome (K_i = 21 nM) and 26S proteasome (K_i = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.

基本信息

经验(实验)分子式	C₂₅H₃₉N₃O₅
分子量	461.59
PubChem化学物质编号	329775129
NACRES	NA.32

产品性质

质量水平	100
测定	≥90% (HPLC)
形式	powder
颜色	white
溶解性	DMSO: soluble
储存温度	−20℃
SMILES string	CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
InChI	1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChI key	QEJRGURBLQWEOU-FKBYEOEOSA-N
Gene Information	human ... PSMA1(5682), PSMC1(5700) mouse ... PSMA1(26440), PSMC1(19179) rat ... PSMA1(29668), PSMC1(117263)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

474780

Sigma-Aldrich

MG-115-CAS 133407-86-0-Calbiochem

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

3352.28元/5 MG;

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产品说明

一般描述

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.

包装

5 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Target K_i: 21 nM and 35 nM for 20S and 26S proteasome, respectively
Cell permeable: no
Reversible: yes
Primary Target
20S proteasome

警告

Toxicity: Standard Handling (A)

序列

Z-Leu-Leu-Nva-CHO

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.
Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₅H₃₉N₃O₅
分子量	461.59

产品性质

质量水平	100
测定	≥90% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

M02121

Fluorochem

Z-Leu-Leu-Nva-aldehyde

>95%

462元/1mg; 1848元/5mg;

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基本信息

CAS Number	133407-86-0
MDL Number	MFCD00671410

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .